Gene Information
Gene NameOCRL
OrganismHomo sapiens (Human)
Gene Length901
Protein NamesInositol polyphosphate 5-phosphatase OCRL (EC 3.1.3.36) (EC 3.1.3.56) (Inositol polyphosphate 5-phosphatase OCRL-1) (OCRL-1) (Lowe oculocerebrorenal syndrome protein) (Phosphatidylinositol 3,4,5-triphosphate 5-phosphatase) (EC 3.1.3.86)
Target NameNA
Target TypeNA
Gene Age680 ( ENSG00000122126 )
Evolutionary StageEukaryota
AlphaFoldDBQ01968
Gene CardOCRL
Uniprot IDQ01968
PfamPF03372; PF16726; PF00620
In ASDno
Allosteric Predictionyes (0.071906582)
Ortholog in AnimalsAlpaca_ OCRL ( ortholog_one2one )
Dog_ OCRL ( ortholog_one2one )
GuineaPig_ OCRL ( ortholog_one2one )
Macaque_ OCRL ( ortholog_one2one )
Mouse_ Ocrl ( ortholog_one2one )
Pig_ OCRL ( ortholog_one2one )
Rat_ Ocrl ( ortholog_one2one )
Rabbit_ OCRL ( ortholog_one2one )
OhnologsINPP5B
ParalogsSH2D1B, SH2D1A, FIG4, INPP5E, SYNJ2, SACM1L, INPP5D, INPPL1, INPP5F, INPP5J, SYNJ1, INPP5B, INPP5K
TissueNA
Tissue SpecificityBrain, skeletal muscle, heart, kidney, lung, placenta and fibroblasts. Expressed in the retina and the retinal pigment epithelium. {ECO:0000269|PubMed:22543976}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2KIE  (NMR  -  )  2QV2  (X-ray  2.40A  )  3QBT  (X-ray  2.00A  )  3QIS  (X-ray  2.30A  )  4CMN  (X-ray  3.13A  ) 
DBSNP rs137853828  rs137853829  rs137853830  rs137853263  rs137853831  rs137853833  rs137853854  rs137853832  rs137853834  rs137853835  rs137853836  rs137853848  rs137853837  rs137853855  rs137853856  rs137853850  rs137853838  rs137853839  rs137853851  rs137853841  rs137853840  rs137853262  rs137853846  rs137853857  rs137853842  rs398123287  rs137853260  rs137853843  rs137853849  rs137853847  rs137853853  rs137853261  rs137853852  rs137853858  rs137853844  rs935956958  rs137853845 
Subcellular location [CC]Cytoplasmic vesicle, phagosome membrane {ECO:0000250|UniProtKB:D3ZGS3}. Early endosome membrane {ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:25869668}. Membrane, clathrin-coated pit {ECO:0000269|PubMed:25869668}. Cell projection, cilium, photoreceptor outer segment {ECO:0000269|PubMed:22543976}. Cell projection, cilium {ECO:0000269|PubMed:22543976}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:D3ZGS3}. Endosome {ECO:0000269|PubMed:21971085, ECO:0000269|PubMed:25869668}. Golgi apparatus, trans-Golgi network {ECO:0000250|UniProtKB:D3ZGS3}. Lysosome {ECO:0000269|PubMed:9430698}. Note=Also found on macropinosomes (PubMed:25869668). Colocalized with APPL1 on phagosomes (PubMed:22072788). {ECO:0000269|PubMed:22072788, ECO:0000269|PubMed:25869668}.
Mouse PG classificationNA
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