| Gene Information | |
|---|---|
| Gene Name | OCLN |
| Organism | Homo sapiens (Human) |
| Gene Length | 522 |
| Protein Names | Occludin |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000197822 ) 3 ( ENSG00000273814 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q16625 |
| Gene Card | OCLN |
| Uniprot ID | Q16625 |
| Pfam | PF01284; PF07303 |
| In ASD | no |
| Allosteric Prediction | yes (0.572030152) |
| Ortholog in Animals | Alpaca_ OCLN ( ortholog_one2one ) Dog_ OCLN ( ortholog_one2one ) GuineaPig_ Ocln ( ortholog_one2one ) Macaque_ OCLN ( ortholog_one2one ) Mouse_ Ocln ( ortholog_one2one ) Pig_ OCLN ( ortholog_one2one ) Rabbit_ OCLN ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | OCEL1, ELL2, ELL3, ELL, MARVELD2 |
| Tissue | NA |
| Tissue Specificity | Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis. {ECO:0000269|PubMed:23239027}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1WPA (X-ray 1.50A ) 1XAW (X-ray 1.45A ) 3G7C (X-ray 2.00A ) |
| DBSNP | rs267606926 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:9175707}; Multi-pass membrane protein {ECO:0000255}. Cell junction, tight junction {ECO:0000269|PubMed:10523508, ECO:0000269|PubMed:19017651, ECO:0000269|PubMed:19114660, ECO:0000269|PubMed:19332538, ECO:0000269|PubMed:23239027, ECO:0000269|PubMed:9175707}. |
| Mouse PG classification | NA |
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