| Gene Information | |
|---|---|
| Gene Name | PRPF19 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Pre-mRNA-processing factor 19 (EC 2.3.2.27) (Nuclear matrix protein 200) (PRP19/PSO4 homolog) (hPso4) (RING-type E3 ubiquitin transferase PRP19) (Senescence evasion factor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000110107 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UMS4 |
| Gene Card | PRPF19 |
| Uniprot ID | Q9UMS4 |
| Pfam | PF08606; PF04564; PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.853298373) |
| Ortholog in Animals | Alpaca_ PRPF19 ( ortholog_one2one ) Dog_ PRPF19 ( ortholog_one2one ) GuineaPig_ PRPF19 ( ortholog_one2one ) Macaque_ PRPF19 ( ortholog_one2one ) Mouse_ Prpf19 ( ortholog_one2one ) Pig_ PRPF19 ( ortholog_one2one ) Rat_ Prpf19 ( ortholog_one2one ) Rabbit_ PRPF19 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | WDR36 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Weakly expressed in senescent cells of different tissue origins. Highly expressed in tumor cell lines. {ECO:0000269|PubMed:10404385, ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:11435423, ECO:0000269|PubMed:12960389, ECO:0000269|PubMed:16388800}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.115291(Mouse);0.028191(Rat);0.145542(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4LG8 (X-ray 1.89A ) 5MQF (EM 5.90A ) 5XJC (EM 3.60A ) 5YZG (EM 4.10A ) 5Z56 (EM 5.10A ) 5Z57 (EM 6.50A ) 6FF7 (EM 4.50A ) 6ICZ (EM 3.00A ) 6ID0 (EM 2.90A ) 6ID1 (EM 2.86A ) 6QDV (EM 3.30A ) 7A5P (EM 5.00A ) 7W59 (EM 3.60A ) 7W5A (EM 3.60A ) 7W5B (EM 4.30A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:19188445, ECO:0000269|PubMed:20176811, ECO:0000269|PubMed:28076346, ECO:0000269|PubMed:28502770, ECO:0000269|PubMed:29301961, ECO:0000269|PubMed:29360106, ECO:0000269|PubMed:30705154}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11082287}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:11082287}. Cytoplasm {ECO:0000269|PubMed:11435423}. Lipid droplet {ECO:0000250|UniProtKB:Q99KP6}. Note=Nucleoplasmic in interphase cells. Irregularly distributed in anaphase cells. In prophase cells, uniformly distributed, but not associated with condensing chromosomes. Found in extrachromosomal regions in metaphase cells. Mainly localized to the mitotic spindle apparatus when chromosomes segregate during anaphase. When nuclei reform during late telophase, uniformly distributed in daughter cells and displays no preferred association with decondensing chromatin. Recruited on damaged DNA at sites of double-strand break. {ECO:0000269|PubMed:11082287, ECO:0000269|PubMed:18263876}. |
| Mouse PG classification | NA |
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