| Gene Information | |
|---|---|
| Gene Name | PTPRO |
| Organism | Homo sapiens (Human) |
| Gene Length | 1216 |
| Protein Names | Receptor-type tyrosine-protein phosphatase O (R-PTP-O) (EC 3.1.3.48) (Glomerular epithelial protein 1) (Protein tyrosine phosphatase U2) (PTP-U2) (PTPase U2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000151490 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q16827 |
| Gene Card | PTPRO |
| Uniprot ID | Q16827 |
| Pfam | PF00041; PF00102 |
| In ASD | no |
| Allosteric Prediction | yes (0.417428331) |
| Ortholog in Animals | Alpaca_ PTPRO ( ortholog_one2one ) Dog_ PTPRO ( ortholog_one2one ) GuineaPig_ PTPRO ( ortholog_one2one ) Macaque_ PTPRO ( ortholog_one2one ) Mouse_ Ptpro ( ortholog_one2one ) Pig_ PTPRO ( ortholog_one2one ) Rat_ Ptpro ( ortholog_one2one ) Rabbit_ PTPRO ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPRZ1, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | cerebral.cortex, colon, kidney, rectum, brain, lung |
| Tissue Specificity | Glomerulus of kidney. Also detected in brain, lung and placenta. {ECO:0000269|PubMed:10498613}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2G59 (X-ray 2.19A ) 2GJT (X-ray 2.15A ) |
| DBSNP | NA |
| Subcellular location [CC] | Membrane; Single-pass type I membrane protein. |
| Mouse PG classification | HPG |
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