| Gene Information | |
|---|---|
| Gene Name | EXOSC9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 439 |
| Protein Names | Exosome complex component RRP45 (Autoantigen PM/Scl 1) (Exosome component 9) (P75 polymyositis-scleroderma overlap syndrome-associated autoantigen) (Polymyositis/scleroderma autoantigen 1) (Polymyositis/scleroderma autoantigen 75 kDa) (PM/Scl-75) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000123737 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q06265 |
| Gene Card | EXOSC9 |
| Uniprot ID | Q06265 |
| Pfam | PF01138; PF03725 |
| In ASD | no |
| Allosteric Prediction | no (-0.942664626) |
| Ortholog in Animals | Alpaca_ EXOSC9 ( ortholog_one2one ) Dog_ EXOSC9 ( ortholog_one2one ) GuineaPig_ EXOSC9 ( ortholog_one2one ) Macaque_ EXOSC9 ( ortholog_one2one ) Mouse_ Exosc9 ( ortholog_one2one ) Pig_ EXOSC9 ( ortholog_one2one ) Rat_ Exosc9 ( ortholog_one2one ) Rabbit_ EXOSC9 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EXOSC8, EXOSC7 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.074168(Rat);0.089027(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2NN6 (X-ray 3.35A ) 6D6Q (EM 3.45A ) 6D6R (EM 3.45A ) 6H25 (EM 3.80A ) |
| DBSNP | rs139632595 rs1803183 rs1051881 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11782436}. Nucleus {ECO:0000269|PubMed:24105744}. Nucleus, nucleolus {ECO:0000269|PubMed:24105744}. Nucleus, nucleoplasm {ECO:0000269|PubMed:24105744}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (PubMed:24105744). {ECO:0000269|PubMed:24105744}.; [Isoform 1]: Nucleus, nucleolus.; [Isoform 2]: Nucleus, nucleolus.; [Isoform 3]: Nucleus. Note=Excluded from the nucleolus. |
| Mouse PG classification | NA |
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