| Gene Information | |
|---|---|
| Gene Name | SIX6 |
| Organism | Homo sapiens (Human) |
| Gene Length | 246 |
| Protein Names | Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000184302 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O95475 |
| Gene Card | SIX6 |
| Uniprot ID | O95475 |
| Pfam | PF00046; PF16878 |
| In ASD | no |
| Allosteric Prediction | no (-1.384738031) |
| Ortholog in Animals | Alpaca_ SIX6 ( ortholog_one2one ) Dog_ SIX6 ( ortholog_one2one ) GuineaPig_ SIX6 ( ortholog_one2one ) Macaque_ SIX6 ( ortholog_one2one ) Mouse_ Six6 ( ortholog_one2one ) Pig_ SIX6 ( ortholog_one2one ) Rat_ Six6 ( ortholog_one2one ) Rabbit_ SIX6 ( ortholog_one2one ) |
| Ohnologs | SIX3 |
| Paralogs | SIX2, ANHX, SIX3, SIX1, SIX4, SIX5 |
| Tissue | pituitary.gland |
| Tissue Specificity | Expressed in the developing and adult retina. Also expressed in the hypothalamic and the pituitary regions. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs33912345 rs104894480 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}. |
| Mouse PG classification | HPG |
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