| Gene Information | |
|---|---|
| Gene Name | PIWIL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 852 |
| Protein Names | Piwi-like protein 4 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000134627 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q7Z3Z4 |
| Gene Card | PIWIL4 |
| Uniprot ID | Q7Z3Z4 |
| Pfam | PF02170; PF02171 |
| In ASD | no |
| Allosteric Prediction | no (-0.704743699) |
| Ortholog in Animals | Alpaca_ PIWIL4 ( ortholog_one2one ) Dog_ PIWIL4 ( ortholog_one2one ) GuineaPig_ PIWIL4 ( ortholog_one2one ) Macaque_ PIWIL4 ( ortholog_one2one ) Mouse_ Piwil4 ( ortholog_one2one ) Pig_ PIWIL4 ( ortholog_one2one ) Rat_ Piwil4 ( ortholog_one2one ) Rabbit_ PIWIL4 ( ortholog_one2one ) |
| Ohnologs | PIWIL1, PIWIL3 |
| Paralogs | PIWIL1, PIWIL3, PIWIL2 |
| Tissue | NA |
| Tissue Specificity | Ubiquitously expressed (PubMed:25038252, PubMed:17544373, PubMed:28025795, PubMed:28711973, PubMed:22483988). Detected in retina, retinal pigment epithelia cells (RPE) (at protein level) (PubMed:28025795). {ECO:0000269|PubMed:17544373, ECO:0000269|PubMed:22483988, ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795, ECO:0000269|PubMed:28711973}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12276921 rs12272255 rs11020845 rs57607909 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Cytoplasm {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:25038252, ECO:0000269|PubMed:28025795}. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. PIWIL2/MILI is required for nuclear localization (By similarity). {ECO:0000250|UniProtKB:Q8CGT6}. |
| Mouse PG classification | NA |
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