| Gene Information | |
|---|---|
| Gene Name | OAT |
| Organism | Homo sapiens (Human) |
| Gene Length | 439 |
| Protein Names | Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form] |
| Target Name | ornithine delta-aminotransferase |
| Target Type | Literature-reported target |
| Gene Age | 1488 ( ENSG00000065154 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P04181 |
| Gene Card | OAT |
| Uniprot ID | P04181 |
| Pfam | PF00202 |
| In ASD | no |
| Allosteric Prediction | yes (0.658346029) |
| Ortholog in Animals | Alpaca_ OAT ( ortholog_one2one ) GuineaPig_ OAT ( ortholog_one2one ) Macaque_ OAT ( ortholog_one2one ) Mouse_ Oat ( ortholog_one2one ) Rat_ Oat ( ortholog_one2one ) Rabbit_ OAT ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PHYKPL, ABAT, ETNPPL, AGXT2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GBN (X-ray 2.30A ) 1OAT (X-ray 2.50A ) 2BYJ (X-ray 3.02A ) 2BYL (X-ray 2.15A ) 2CAN (X-ray 2.30A ) 2OAT (X-ray 1.95A ) 5VWO (X-ray 1.77A ) 6HX7 (X-ray 1.80A ) 6OIA (X-ray 1.78A ) 6V8C (X-ray 1.90A ) 6V8D (X-ray 2.25A ) 7JX9 (X-ray 1.96A ) 7LK0 (X-ray 1.96A ) 7LK1 (X-ray 1.79A ) 7LNM (X-ray 2.00A ) 7LOM (X-ray 2.10A ) 7LON (X-ray 1.95A ) 7T9Z (X-ray 2.15A ) 7TA0 (X-ray 2.33A ) 7TA1 (X-ray 2.20A ) 7TED (X-ray 2.63A ) 7TEV (X-ray 1.91A ) 7TFP (X-ray 2.71A ) |
| DBSNP | rs11553554 rs121965048 rs121965037 rs386833602 rs121965060 rs121965038 rs386833604 rs121965039 rs121965040 rs121965035 rs267606925 rs121965059 rs121965051 rs121965046 rs121965052 rs386833618 rs121965041 rs121965042 rs386833621 rs121965049 rs121965047 rs121965053 rs121965045 rs121965054 rs386833597 rs121965043 rs121965044 rs386833598 rs1800456 |
| Subcellular location [CC] | Mitochondrion matrix {ECO:0000269|PubMed:23076989}. |
| Mouse PG classification | NA |
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