| Gene Information | |
|---|---|
| Gene Name | WT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 449 |
| Protein Names | Wilms tumor protein (WT33) |
| Target Name | wilms tumor protein |
| Target Type | Clinical trial target |
| Gene Age | 645 ( ENSG00000184937 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | P19544 |
| Gene Card | WT1 |
| Uniprot ID | P19544 |
| Pfam | PF02165; PF00096 |
| In ASD | no |
| Allosteric Prediction | no (-0.293414335) |
| Ortholog in Animals | Alpaca_ WT1 ( ortholog_one2one ) Dog_ WT1 ( ortholog_one2one ) GuineaPig_ WT1 ( ortholog_one2one ) Macaque_ WT1 ( ortholog_one2one ) Mouse_ Wt1 ( ortholog_one2one ) Pig_ WT1 ( ortholog_one2one ) Rat_ Wt1 ( ortholog_one2one ) Rabbit_ WT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EGR2, EGR3, EGR4, EGR1 |
| Tissue | endometrium, ovary, testis, oviduct, smooth.muscle, uterus |
| Tissue Specificity | Expressed in the kidney and a subset of hematopoietic cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1XF7 (NMR - ) 2JP9 (NMR - ) 2JPA (NMR - ) 2PRT (X-ray 3.15A ) 3HPJ (X-ray 2.00A ) 3MYJ (X-ray 1.89A ) 4R2E (X-ray 1.84A ) 4R2P (X-ray 1.79A ) 4R2Q (X-ray 1.54A ) 4R2R (X-ray 2.09A ) 4R2S (X-ray 2.49A ) 4WUU (X-ray 3.05A ) 5KL2 (X-ray 1.69A ) 5KL3 (X-ray 1.45A ) 5KL4 (X-ray 1.78A ) 5KL5 (X-ray 2.29A ) 5KL6 (X-ray 1.64A ) 5KL7 (X-ray 1.58A ) 6B0O (X-ray 1.55A ) 6B0P (X-ray 2.08A ) 6B0Q (X-ray 2.79A ) 6B0R (X-ray 1.82A ) 6BLW (X-ray 1.83A ) 6RSY (X-ray 2.95A ) 6WLH (NMR - ) 7BBG (X-ray 2.64A ) |
| DBSNP | rs2234584 rs121907908 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15520190}. Nucleus, nucleolus. Cytoplasm {ECO:0000250}. Note=Isoforms lacking the KTS motif have a diffuse nuclear location (PubMed:15520190). Shuttles between nucleus and cytoplasm. {ECO:0000250, ECO:0000269|PubMed:15520190}.; [Isoform 1]: Nucleus speckle {ECO:0000269|PubMed:15520190}.; [Isoform 4]: Nucleus, nucleoplasm {ECO:0000269|PubMed:15520190}. |
| Mouse PG classification | HPG |
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