| Gene Information | |
|---|---|
| Gene Name | Nbla00127 |
| Organism | Homo sapiens (Human) |
| Gene Length | 982 |
| Protein Names | E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q13191 |
| Gene Card | CBLB |
| Uniprot ID | Q13191 |
| Pfam | PF02262; PF02761; PF02762 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle. Present in lymphocytes (at protein level). {ECO:0000269|PubMed:10022120, ECO:0000269|PubMed:9399639}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2AK5 (X-ray 1.85A ) 2BZ8 (X-ray 2.00A ) 2DO6 (NMR - ) 2J6F (X-ray 1.70A ) 2JNH (NMR - ) 2LDR (NMR - ) 2OOA (X-ray 1.56A ) 2OOB (X-ray 1.90A ) 3PFV (X-ray 2.27A ) 3VGO (X-ray 3.10A ) 3ZNI (X-ray 2.21A ) |
| DBSNP | rs17853100 rs35835913 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12177062}. Note=Upon EGF stimulation, associates with endocytic vesicles. |
| Mouse PG classification | NA |
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