Gene Information
Gene NameKLHL12
OrganismHomo sapiens (Human)
Gene Length568
Protein NamesKelch-like protein 12 (CUL3-interacting protein 1) (DKIR homolog) (hDKIR)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000117153 )
Evolutionary StageEumetazoa
AlphaFoldDBQ53G59
Gene CardKLHL12
Uniprot IDQ53G59
PfamPF07707; PF00651; PF01344
In ASDno
Allosteric Predictionno (-0.781585094)
Ortholog in AnimalsAlpaca_ KLHL12 ( ortholog_one2one )
GuineaPig_ KLHL12 ( ortholog_one2one )
Macaque_ KLHL12 ( ortholog_one2one )
Mouse_ Klhl12 ( ortholog_one2one )
Pig_ KLHL12 ( ortholog_one2one )
Rat_ Klhl12 ( ortholog_one2one )
Rabbit_ KLHL12 ( ortholog_one2one )
OhnologsNA
ParalogsKLHL40, KLHDC7B, GAN, BACH1, KLHL20, KLHL10, KLHL42, KLHL21, KLHL32, KBTBD7, KBTBD6, BACH2, KLHL30, KLHL15, KLHL38, KLHL41, KLHL26, KLHL17, KBTBD3, KLHL13, KLHL9, KLHL18, KLHL23, KLHDC7A, KLHL31, IVNS1ABP, KLHL1, KEAP1, KLHL8, KLHL2, KLHL29, KBTBD12, KLHL34, KLHL7, KLHL33, KLHL36, KLHL28, KBTBD11, KLHL14, CCIN, BTBD18, IPP, KLHDC8B, KLHL6, KLHL24, KLHL5, KBTBD13, KBTBD8, KLHL3, KLHL35, KLHL22, KBTBD2, KLHL4, KLHDC8A
TissueNA
Tissue SpecificityUbiquitously expressed. Highly expressed in testis and at lower levels in the submandibular salivary gland. {ECO:0000269|PubMed:15383316, ECO:0000269|PubMed:16108817}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2VPJ  (X-ray  1.85A  6TTK  (X-ray  2.38A  6V7O  (X-ray  2.90A 
DBSNP rs12569087 
Subcellular location [CC]Cytoplasmic vesicle, COPII-coated vesicle {ECO:0000269|PubMed:22358839, ECO:0000269|PubMed:27716508}.
Mouse PG classificationNA
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