| Gene Information | |
|---|---|
| Gene Name | NVL |
| Organism | Homo sapiens (Human) |
| Gene Length | 856 |
| Protein Names | Nuclear valosin-containing protein-like (NVLp) (Nuclear VCP-like protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000143748 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | O15381 |
| Gene Card | NVL |
| Uniprot ID | O15381 |
| Pfam | PF00004; PF17862; PF16725 |
| In ASD | no |
| Allosteric Prediction | yes (0.031766879) |
| Ortholog in Animals | Alpaca_ NVL ( ortholog_one2one ) Dog_ NVL ( ortholog_one2one ) GuineaPig_ NVL ( ortholog_one2one ) Macaque_ NVL ( ortholog_one2one ) Mouse_ Nvl ( ortholog_one2one ) Pig_ NVL ( ortholog_one2one ) Rat_ Nvl ( ortholog_one2one ) Rabbit_ NVL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | VCP, PEX6, SPATA5L1, PEX1, SPATA5 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina. {ECO:0000269|PubMed:9286697}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.018182(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2X8A (X-ray 2.60A ) 6RO1 (X-ray 3.07A ) |
| DBSNP | rs12084919 rs34631151 |
| Subcellular location [CC] | [Isoform 2]: Nucleus, nucleoplasm {ECO:0000269|PubMed:15469983}.; [Isoform 1]: Nucleus, nucleolus {ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:15469983, ECO:0000269|PubMed:22226966, ECO:0000269|PubMed:26456651, ECO:0000269|PubMed:9286697}. Nucleus, nucleoplasm {ECO:0000269|PubMed:15469983}. Note=Expressed predominantly in the nucleolus. Associates with pre-ribosomal particles in the nucleus. {ECO:0000269|PubMed:16782053}. |
| Mouse PG classification | NA |
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