Gene Information | |
---|---|
Gene Name | NUP50 |
Organism | Homo sapiens (Human) |
Gene Length | 468 |
Protein Names | Nuclear pore complex protein Nup50 (50 kDa nucleoporin) (Nuclear pore-associated protein 60 kDa-like) (Nucleoporin Nup50) |
Target Name | NA |
Target Type | NA |
Gene Age | 544 ( ENSG00000093000 ) |
Evolutionary Stage | Eukaryota |
AlphaFoldDB | Q9UKX7 |
Gene Card | NUP50 |
Uniprot ID | Q9UKX7 |
Pfam | PF08911; PF00638 |
In ASD | no |
Allosteric Prediction | no (-0.328450004) |
Ortholog in Animals | Alpaca_ NUP50 ( ortholog_one2one ) Dog_ NUP50 ( ortholog_one2one ) GuineaPig_ NUP50 ( ortholog_one2one ) Macaque_ NUP50 ( ortholog_one2one ) Mouse_ 1700123L14Rik ( ortholog_one2many ) Mouse_ Nup50 ( ortholog_one2many ) Pig_ NUP50 ( ortholog_one2one ) Rat_ Nup50 ( ortholog_one2many ) Rabbit_ NUP50 ( ortholog_one2one ) |
Ohnologs | NA |
Paralogs | NA |
Tissue | NA |
Tissue Specificity | Ubiquitous. Highest levels in testis, peripheral blood leukocytes and fetal liver. |
Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001490(Rat);NULL(Rabbit) |
Gene Ontology (biological process) |
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Gene Ontology (cellular component) |
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Gene Ontology (molecular function) |
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PDB | 2EC1 (NMR - ) 3TJ3 (X-ray 2.70A ) 7MO0 (X-ray 2.45A ) |
DBSNP | NA |
Subcellular location [CC] | Nucleus, nuclear pore complex {ECO:0000269|PubMed:12802065}. Nucleus membrane {ECO:0000250|UniProtKB:O08587}; Peripheral membrane protein {ECO:0000250|UniProtKB:O08587}; Nucleoplasmic side {ECO:0000250|UniProtKB:O08587}. Note=Localizes to the nucleoplasmic fibrils of the nuclear pore complex (By similarity). Dissociates from the NPC structure early during prophase of mitosis (PubMed:12802065). Associates with the newly formed nuclear membrane during telophase (PubMed:12802065). In the testis, the localization changes during germ cell differentiation from the nuclear surface in spermatocytes to the whole nucleus (interior) in spermatids and back to the nuclear surface in spermatozoa (By similarity). {ECO:0000250|UniProtKB:O08587, ECO:0000269|PubMed:12802065}. |
Mouse PG classification | NA |
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