| Gene Information | |
|---|---|
| Gene Name | LCN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 198 |
| Protein Names | Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25) |
| Target Name | neutrophil gelatinase-associated lipocalin |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000148346 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P80188 |
| Gene Card | LCN2 |
| Uniprot ID | P80188 |
| Pfam | PF00061 |
| In ASD | no |
| Allosteric Prediction | yes (0.280009569) |
| Ortholog in Animals | Alpaca_ LCN2 ( ortholog_one2many ) Dog_ LCN2 ( ortholog_one2one ) Macaque_ LCN2 ( ortholog_one2one ) Mouse_ Lcn2 ( ortholog_one2one ) Pig_ LCN2 ( ortholog_one2one ) Rat_ Lcn2 ( ortholog_one2one ) Rabbit_ LCN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | LCN12, PTGDS, LCN8, LCN1, LCN9, LCN10, PAEP, OBP2A, LCN6, OBP2B, LCN15, LCNL1 |
| Tissue | esophagus.mucosa, minor.salivary.gland |
| Tissue Specificity | Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:7683678, ECO:0000269|PubMed:8298140, ECO:0000269|PubMed:9339356}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1DFV (X-ray 2.60A ) 1L6M (X-ray 2.40A ) 1NGL (NMR - ) 1QQS (X-ray 2.40A ) 1X71 (X-ray 2.10A ) 1X89 (X-ray 2.10A ) 1X8U (X-ray 2.20A ) 3BY0 (X-ray 2.57A ) 3CBC (X-ray 2.17A ) 3CMP (X-ray 2.80A ) 3DSZ (X-ray 2.00A ) 3DTQ (X-ray 2.50A ) 3FW4 (X-ray 2.30A ) 3FW5 (X-ray 2.30A ) 3HWD (X-ray 2.95A ) 3HWE (X-ray 2.80A ) 3HWF (X-ray 3.20A ) 3HWG (X-ray 2.19A ) 3I0A (X-ray 2.60A ) 3K3L (X-ray 2.62A ) 3PEC (X-ray 2.19A ) 3PED (X-ray 2.30A ) 3T1D (X-ray 2.30A ) 3TF6 (X-ray 2.35A ) 3TZS (X-ray 2.45A ) 3U0D (X-ray 2.51A ) 4GH7 (X-ray 2.60A ) 4IAW (X-ray 2.40A ) 4IAX (X-ray 1.90A ) 4K19 (X-ray 2.74A ) 4MVI (X-ray 1.70A ) 4MVK (X-ray 1.50A ) 4MVL (X-ray 2.30A ) 4QAE (X-ray 2.10A ) 4ZFX (X-ray 2.55A ) 4ZHC (X-ray 2.04A ) 4ZHD (X-ray 2.05A ) 4ZHF (X-ray 2.45A ) 4ZHG (X-ray 2.05A ) 4ZHH (X-ray 2.04A ) 5JR8 (X-ray 2.65A ) 5KHP (X-ray 2.65A ) 5KIC (X-ray 2.70A ) 5KID (X-ray 2.15A ) 5MHH (X-ray 2.00A ) 5N47 (X-ray 3.00A ) 5N48 (X-ray 1.60A ) 5NKN (X-ray 2.20A ) 6GQZ (X-ray 1.40A ) 6GR0 (X-ray 2.50A ) 6O5D (X-ray 2.40A ) 6QMU (X-ray 1.98A ) 6S8V (X-ray 1.80A ) 6SUA (X-ray 2.75A ) 6Z2C (X-ray 1.80A ) 6Z6Z (X-ray 1.78A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:27780864, ECO:0000269|PubMed:7683678}. Cytoplasmic granule lumen {ECO:0000269|PubMed:8298140}. Cytoplasmic vesicle lumen {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized (By similarity). Releases the bound iron in the acidic lumen of cytoplasmic vesicles (PubMed:12453413, PubMed:20581821). {ECO:0000250|UniProtKB:P11672, ECO:0000269|PubMed:12453413, ECO:0000269|PubMed:20581821}. |
| Mouse PG classification | NA |
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