| Gene Information | |
|---|---|
| Gene Name | NUDT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 156 |
| Protein Names | Oxidized purine nucleoside triphosphate hydrolase (EC 3.6.1.56) (2-hydroxy-dATP diphosphatase) (7,8-dihydro-8-oxoguanine triphosphatase) (8-oxo-dGTPase) (Methylated purine nucleoside triphosphate hydrolase) (EC 3.6.1.-) (Nucleoside diphosphate-linked moiety X motif 1) (Nudix motif 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000106268 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P36639 |
| Gene Card | NUDT1 |
| Uniprot ID | P36639 |
| Pfam | PF00293 |
| In ASD | no |
| Allosteric Prediction | no (-0.433727591) |
| Ortholog in Animals | Alpaca_ NUDT1 ( ortholog_one2one ) GuineaPig_ NUDT1 ( ortholog_one2one ) Macaque_ NUDT1 ( ortholog_one2one ) Mouse_ Nudt1 ( ortholog_one2one ) Pig_ NUDT1 ( ortholog_one2one ) Rat_ Nudt1 ( ortholog_one2one ) Rabbit_ NUDT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NUDT12, NUDT17, NUDT18 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes. {ECO:0000269|PubMed:9211940}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1IRY (NMR - ) 3Q93 (X-ray 1.80A ) 3WHW (X-ray 2.70A ) 3ZR0 (X-ray 1.80A ) 3ZR1 (X-ray 1.90A ) 4C9W (X-ray 1.65A ) 4C9X (X-ray 1.20A ) 4N1T (X-ray 1.60A ) 4N1U (X-ray 1.60A ) 5ANS (X-ray 1.60A ) 5ANT (X-ray 2.00A ) 5ANU (X-ray 1.80A ) 5ANV (X-ray 1.16A ) 5ANW (X-ray 1.37A ) 5FSI (X-ray 1.63A ) 5FSK (X-ray 1.56A ) 5FSL (X-ray 1.24A ) 5FSM (X-ray 1.67A ) 5FSN (X-ray 1.69A ) 5FSO (X-ray 1.67A ) 5GHI (X-ray 1.21A ) 5GHJ (X-ray 1.20A ) 5GHM (X-ray 1.50A ) 5GHN (X-ray 1.39A ) 5GHO (X-ray 1.19A ) 5GHP (X-ray 1.19A ) 5GHQ (X-ray 1.18A ) 5NGR (X-ray 2.20A ) 5NGS (X-ray 1.85A ) 5NGT (X-ray 1.54A ) 5NHY (X-ray 1.72A ) 5OTM (X-ray 1.80A ) 5WS7 (X-ray 1.00A ) 6AA3 (X-ray 2.00A ) 6AA4 (X-ray 1.90A ) 6AA5 (X-ray 1.90A ) 6EQ2 (X-ray 1.80A ) 6EQ3 (X-ray 1.80A ) 6EQ4 (X-ray 1.40A ) 6EQ5 (X-ray 1.80A ) 6EQ6 (X-ray 2.00A ) 6EQ7 (X-ray 1.50A ) 6F1X (X-ray 1.90A ) 6F20 (X-ray 2.00A ) 6F22 (X-ray 1.55A ) 6F23 (X-ray 1.84A ) 6GLE (X-ray 1.40A ) 6GLF (X-ray 2.00A ) 6GLG (X-ray 1.31A ) 6GLH (X-ray 1.20A ) 6GLI (X-ray 1.60A ) 6GLJ (X-ray 1.30A ) 6GLK (X-ray 1.50A ) 6GLL (X-ray 1.40A ) 6GLM (X-ray 1.60A ) 6GLN (X-ray 1.40A ) 6GLO (X-ray 1.70A ) 6GLP (X-ray 1.50A ) 6GLQ (X-ray 1.60A ) 6GLR (X-ray 1.60A ) 6GLS (X-ray 1.50A ) 6GLT (X-ray 1.60A ) 6GLU (X-ray 1.70A ) 6GLV (X-ray 1.60A ) 6IJY (X-ray 1.04A ) 6ILI (X-ray 1.45A ) 6IMZ (X-ray 2.10A ) 6JVF (X-ray 1.73A ) 6JVG (X-ray 1.84A ) 6JVH (X-ray 2.04A ) 6JVI (X-ray 2.25A ) 6JVJ (X-ray 2.30A ) 6JVK (X-ray 2.10A ) 6JVL (X-ray 1.90A ) 6JVM (X-ray 2.10A ) 6JVN (X-ray 2.10A ) 6JVO (X-ray 1.90A ) 6JVP (X-ray 2.21A ) 6JVQ (X-ray 2.20A ) 6JVR (X-ray 2.29A ) 6JVS (X-ray 2.10A ) 6JVT (X-ray 1.80A ) 6QVO (X-ray 2.45A ) 6US2 (X-ray 1.80A ) 6US3 (X-ray 1.47A ) 6US4 (X-ray 1.95A ) 7ESF (X-ray 1.55A ) 7N03 (X-ray 1.13A ) 7N13 (X-ray 1.59A ) |
| DBSNP | rs11547459 rs4866 |
| Subcellular location [CC] | [Isoform p18]: Cytoplasm, cytosol {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}. Mitochondrion matrix {ECO:0000269|PubMed:7782328, ECO:0000305|PubMed:12857738, ECO:0000305|PubMed:16607562}. Nucleus {ECO:0000269|PubMed:12857738, ECO:0000269|PubMed:7782328}. Note=Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). {ECO:0000269|PubMed:16607562, ECO:0000269|PubMed:7782328}.; [Isoform p26]: Mitochondrion matrix {ECO:0000269|PubMed:16607562}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |