| Gene Information | |
|---|---|
| Gene Name | NUCB2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 420 |
| Protein Names | Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1] |
| Target Name | nucleobindin-2 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000070081 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P80303 |
| Gene Card | NUCB2 |
| Uniprot ID | P80303 |
| Pfam | PF13499 |
| In ASD | no |
| Allosteric Prediction | yes (0.083576286) |
| Ortholog in Animals | Alpaca_ NUCB2 ( ortholog_one2one ) Dog_ NUCB2 ( ortholog_one2one ) GuineaPig_ NUCB2 ( ortholog_one2one ) Macaque_ NUCB2 ( ortholog_one2one ) Mouse_ Nucb2 ( ortholog_one2one ) Rat_ Nucb2 ( ortholog_one2one ) Rabbit_ NUCB2 ( ortholog_one2one ) |
| Ohnologs | NUCB1 |
| Paralogs | NUCB1 |
| Tissue | parotid.gland, pituitary.gland, submandibular.gland |
| Tissue Specificity | Predominantly expressed in spleen, testis and normal stomach. {ECO:0000269|PubMed:12087473}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs757081 |
| Subcellular location [CC] | Golgi apparatus {ECO:0000269|PubMed:11749975}. Membrane {ECO:0000269|PubMed:11749975}; Peripheral membrane protein {ECO:0000269|PubMed:11749975}. Cytoplasm {ECO:0000269|PubMed:11749975}. Secreted {ECO:0000269|PubMed:11749975}. Endoplasmic reticulum {ECO:0000250}. Nucleus envelope {ECO:0000250}. Note=Golgi retention is mediated by its N-terminal region.; [Nesfatin-1]: Secreted. |
| Mouse PG classification | NA |
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