| Gene Information | |
|---|---|
| Gene Name | IGF1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 195 |
| Protein Names | Insulin-like growth factor I (IGF-I) (Mechano growth factor) (MGF) (Somatomedin-C) |
| Target Name | insulin-like growth factor i |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000017427 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P05019 |
| Gene Card | IGF1 |
| Uniprot ID | P05019 |
| Pfam | PF00049 |
| In ASD | no |
| Allosteric Prediction | yes (0.873742583) |
| Ortholog in Animals | Alpaca_ IGF1 ( ortholog_one2one ) Dog_ IGF1 ( ortholog_one2one ) GuineaPig_ IGF1 ( ortholog_one2one ) Macaque_ IGF1 ( ortholog_one2one ) Mouse_ Igf1 ( ortholog_one2one ) Pig_ IGF1 ( ortholog_one2one ) Rat_ Igf1 ( ortholog_one2one ) Rabbit_ IGF1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | INS, IGF2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.003717(Rat);0.06(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | 1B9G (NMR - ) 1BQT (NMR - ) 1GZR (X-ray 2.00A ) 1GZY (X-ray 2.54A ) 1GZZ (X-ray 2.30A ) 1H02 (X-ray 2.00A ) 1H59 (X-ray 2.10A ) 1IMX (X-ray 1.82A ) 1PMX (NMR - ) 1TGR (X-ray 1.42A ) 1WQJ (X-ray 1.60A ) 2DSP (X-ray 2.50A ) 2DSQ (X-ray 2.80A ) 2DSR (X-ray 2.10A ) 2GF1 (NMR - ) 3GF1 (NMR - ) 3LRI (NMR - ) 4XSS (X-ray 3.00A ) 5U8Q (X-ray 3.27A ) 6FF3 (X-ray 2.57A ) 6PYH (EM 4.30A ) 6RVA (NMR - ) 7S0Q (EM 3.70A ) 7WRQ (EM 3.60A ) |
| DBSNP | rs587779350 rs17884626 rs6213 |
| Subcellular location [CC] | Secreted {ECO:0000250|UniProtKB:P05017}. |
| Mouse PG classification | LPG |
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