| Gene Information | |
|---|---|
| Gene Name | GLRA3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 464 |
| Protein Names | Glycine receptor subunit alpha-3 |
| Target Name | glycine receptor subunit alpha-3 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000145451 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O75311 |
| Gene Card | GLRA3 |
| Uniprot ID | O75311 |
| Pfam | PF02931; PF02932 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999746036) |
| Ortholog in Animals | Alpaca_ GLRA3 ( ortholog_one2one ) Dog_ GLRA3 ( ortholog_one2one ) GuineaPig_ GLRA3 ( ortholog_one2one ) Macaque_ GLRA3 ( ortholog_one2one ) Mouse_ Glra3 ( ortholog_one2one ) Pig_ GLRA3 ( ortholog_one2one ) Rat_ Glra3 ( ortholog_one2one ) Rabbit_ GLRA3 ( ortholog_one2one ) |
| Ohnologs | GABRA3, GABRP, GLRA2, GABRA6, GLRA1, GLRA4 |
| Paralogs | CHRNB1, GABRR2, CHRNA6, CHRNB4, CHRNA4, GABRQ, HTR3E, CHRNA1, CHRNA3, GABRA5, GLRA2, HTR3B, GLRA1, GABRG3, GABRA2, GABRB3, GABRP, HTR3C, HTR3D, GABRG1, CHRNA7, CHRFAM7A, GABRD, GABRR1, CHRNA5, GABRA6, GABRA4, GABRE, CHRNE, GABRG2, CHRND, CHRNA2, CHRNA10, CHRNA9, GABRA3, HTR3A, ZACN, CHRNB3, CHRNB2, CHRNG, GABRR3, GABRB2, GABRB1, GABRA1, GLRB |
| Tissue | NA |
| Tissue Specificity | Widely distributed throughout the central nervous system. {ECO:0000269|PubMed:9677400}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5CFB (X-ray 3.04A ) 5TIN (X-ray 2.61A ) 5TIO (X-ray 3.25A ) 5VDH (X-ray 2.85A ) 5VDI (X-ray 3.10A ) |
| DBSNP | NA |
| Subcellular location [CC] | Postsynaptic cell membrane {ECO:0000250|UniProtKB:P24524}; Multi-pass membrane protein {ECO:0000305}. Perikaryon {ECO:0000250|UniProtKB:P24524}. Cell projection, dendrite {ECO:0000250|UniProtKB:P24524}. Synapse {ECO:0000250|UniProtKB:P24524}. Cell membrane {ECO:0000269|PubMed:26416729, ECO:0000269|PubMed:9677400}; Multi-pass membrane protein {ECO:0000269|PubMed:26416729}. Note=Partially colocalizes with GPHN that is known to mediate receptor clustering at postsynaptic membranes. {ECO:0000250|UniProtKB:P24524}. |
| Mouse PG classification | NA |
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