| Gene Information | |
|---|---|
| Gene Name | DGKH |
| Organism | Homo sapiens (Human) |
| Gene Length | 1220 |
| Protein Names | Diacylglycerol kinase eta (DAG kinase eta) (EC 2.7.1.107) (Diglyceride kinase eta) (DGK-eta) |
| Target Name | diacylglycerol kinase |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000102780 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q86XP1 |
| Gene Card | DGKH |
| Uniprot ID | Q86XP1 |
| Pfam | PF00130; PF00609; PF00781; PF00169; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.100457537) |
| Ortholog in Animals | Alpaca_ DGKH ( ortholog_one2one ) Dog_ DGKH ( ortholog_one2one ) GuineaPig_ DGKH ( ortholog_one2one ) Macaque_ DGKH ( ortholog_one2one ) Mouse_ Dgkh ( ortholog_one2one ) Pig_ DGKH ( ortholog_one2one ) Rat_ Dgkh ( ortholog_one2one ) Rabbit_ DGKH ( ortholog_one2one ) |
| Ohnologs | DGKD |
| Paralogs | DGKQ, DGKE, DGKG, DGKI, DGKB, DGKD, DGKA, DGKK, DGKZ |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: Expressed only in testis, kidney and colon. {ECO:0000269|PubMed:12810723}.; [Isoform 2]: Ubiquitously expressed. {ECO:0000269|PubMed:12810723}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs17646069 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}. Cell membrane {ECO:0000269|PubMed:12810723, ECO:0000269|PubMed:19710016}. Note=Translocated from the cytoplasm to endosomes in response to stress stimuli (PubMed:12810723). Isoform 2 is rapidly relocated back to the cytoplasm upon removal of stress stimuli, whereas isoform 1 exhibits sustained endosomal association (PubMed:12810723). Translocates from the cytoplasm to the cell membrane in the presence of active GTP-bound form of HRAS (PubMed:19710016). |
| Mouse PG classification | NA |
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