| Gene Information | |
|---|---|
| Gene Name | PTPRZ1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2315 |
| Protein Names | Receptor-type tyrosine-protein phosphatase zeta (R-PTP-zeta) (EC 3.1.3.48) (Protein-tyrosine phosphatase receptor type Z polypeptide 1) (Protein-tyrosine phosphatase receptor type Z polypeptide 2) (R-PTP-zeta-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000106278 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P23471 |
| Gene Card | PTPRZ1 |
| Uniprot ID | P23471 |
| Pfam | PF00194; PF00041; PF00102 |
| In ASD | yes |
| Allosteric Prediction | yes (0.382128013) |
| Ortholog in Animals | Alpaca_ PTPRZ1 ( ortholog_one2one ) Dog_ PTPRZ1 ( ortholog_one2one ) GuineaPig_ PTPRZ1 ( ortholog_one2one ) Macaque_ PTPRZ1 ( ortholog_one2one ) Mouse_ Ptprz1 ( ortholog_one2one ) Pig_ PTPRZ1 ( ortholog_one2one ) Rat_ Ptprz1 ( ortholog_one2one ) Rabbit_ PTPRZ1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PTPN12, PTPRC, PTPN6, PTPN18, PTPN7, PTPN1, PTPN13, PTPRF, PTPRK, PTPRB, PTPRA, PTPN22, PTPRG, PTPRR, PTPN5, PTPN23, PTPN9, PTPRE, PTPN4, PTPRT, PTPRS, PTPRD, PTPN2, PTPRO, PTPRJ, PTPRM, PTPN11, PTPN20, PTPRU, PTPN14, PTPN3, PTPRN, PTPRN2, PTPRH, PTPN21 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain. {ECO:0000269|PubMed:9653645}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 3JXF (X-ray 2.00A ) 3S97 (X-ray 2.30A ) 5AWX (X-ray 1.86A ) 5H08 (X-ray 2.53A ) |
| DBSNP | rs740965 rs11980387 rs1147504 |
| Subcellular location [CC] | [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Secreted {ECO:0000250}. Note=A secreted form is apparently generated by shedding of the extracellular domain. {ECO:0000250}.; [Isoform 2]: Secreted {ECO:0000305}. |
| Mouse PG classification | NA |
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