| Gene Information | |
|---|---|
| Gene Name | NTHL1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 312 |
| Protein Names | Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000065057 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P78549 |
| Gene Card | NTHL1 |
| Uniprot ID | P78549 |
| Pfam | PF00633; PF00730 |
| In ASD | no |
| Allosteric Prediction | no (-0.441352534) |
| Ortholog in Animals | Alpaca_ NTHL1 ( ortholog_one2one ) Dog_ NTHL1 ( ortholog_one2one ) GuineaPig_ NTHL1 ( ortholog_one2one ) Macaque_ NTHL1 ( ortholog_one2one ) Mouse_ Nthl1 ( ortholog_one2one ) Pig_ NTHL1 ( ortholog_one2one ) Rat_ Nthl1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MUTYH |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest levels in heart and lowest levels in lung and liver. {ECO:0000269|PubMed:8990169, ECO:0000269|PubMed:9831664}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7RDS (X-ray 2.50A ) 7RDT (X-ray 2.10A ) |
| DBSNP | rs3087469 rs2302172 rs1805378 rs3211977 rs3087468 |
| Subcellular location [CC] | Nucleus {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:10882850, ECO:0000269|PubMed:12531031, ECO:0000269|PubMed:9611236}. Mitochondrion {ECO:0000255|HAMAP-Rule:MF_03183, ECO:0000269|PubMed:9611236}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |