| Gene Information | |
|---|---|
| Gene Name | NT5C3A |
| Organism | Homo sapiens (Human) |
| Gene Length | 336 |
| Protein Names | Cytosolic 5'-nucleotidase 3A (EC 3.1.3.5) (7-methylguanosine phosphate-specific 5'-nucleotidase) (7-methylguanosine nucleotidase) (EC 3.1.3.91) (Cytosolic 5'-nucleotidase 3) (Cytosolic 5'-nucleotidase III) (cN-III) (Pyrimidine 5'-nucleotidase 1) (P5'N-1) (P5N-1) (PN-I) (Uridine 5'-monophosphate hydrolase 1) (p36) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000122643 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9H0P0 |
| Gene Card | NT5C3A |
| Uniprot ID | Q9H0P0 |
| Pfam | PF05822 |
| In ASD | no |
| Allosteric Prediction | yes (0.385701797) |
| Ortholog in Animals | Alpaca_ NT5C3A ( ortholog_one2one ) Alpaca_ NT5C3A ( ortholog_one2many ) Dog_ NT5C3A ( ortholog_one2one ) GuineaPig_ NT5C3A ( ortholog_one2one ) Macaque_ NT5C3A ( ortholog_one2one ) Mouse_ Nt5c3 ( ortholog_one2one ) Pig_ NT5C3A ( ortholog_one2one ) Rat_ Nt5c3a ( ortholog_one2one ) Rabbit_ NT5C3A ( ortholog_one2one ) |
| Ohnologs | NT5C3B |
| Paralogs | NT5C3B |
| Tissue | NA |
| Tissue Specificity | Isoforms 1, 3 and 4 are expressed in reticulocytes. Isoform 4 is hardly detectable in bone marrow and fetal liver. {ECO:0000269|PubMed:11369620, ECO:0000269|PubMed:15238149}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2CN1 (X-ray 2.67A ) 2JGA (X-ray 3.01A ) 2VKQ (X-ray 2.50A ) |
| DBSNP | rs766577643 rs104894025 rs104894028 rs104894029 |
| Subcellular location [CC] | Cytoplasm {ECO:0000305}.; [Isoform 2]: Endoplasmic reticulum. |
| Mouse PG classification | NA |
| click here to return to the previous page | |