| Gene Information | |
|---|---|
| Gene Name | NT5C2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 561 |
| Protein Names | Cytosolic purine 5'-nucleotidase (EC 3.1.3.5) (EC 3.1.3.99) (Cytosolic 5'-nucleotidase II) (cN-II) (Cytosolic IMP/GMP-specific 5'-nucleotidase) (Cytosolic nucleoside phosphotransferase 5'N) (EC 2.7.1.77) (High Km 5'-nucleotidase) |
| Target Name | cytosolic purine 5'-nucleotidase |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000076685 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49902 |
| Gene Card | NT5C2 |
| Uniprot ID | P49902 |
| Pfam | PF05761 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999937725) |
| Ortholog in Animals | Alpaca_ NT5C2 ( ortholog_one2one ) Dog_ NT5C2 ( ortholog_one2one ) GuineaPig_ NT5C2 ( ortholog_one2one ) Macaque_ NT5C2 ( ortholog_one2one ) Mouse_ Nt5c2 ( ortholog_one2one ) Pig_ NT5C2 ( ortholog_one2one ) Rat_ Nt5c2 ( ortholog_one2many ) |
| Ohnologs | NT5DC4 |
| Paralogs | NT5DC4, NT5DC1, NT5DC3, NT5DC2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:9371705}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2J2C (X-ray 2.20A ) 2JC9 (X-ray 1.50A ) 2JCM (X-ray 2.15A ) 2XCV (X-ray 2.30A ) 2XCW (X-ray 1.90A ) 2XCX (X-ray 2.30A ) 2XJB (X-ray 2.30A ) 2XJC (X-ray 2.00A ) 2XJD (X-ray 2.00A ) 2XJE (X-ray 2.30A ) 2XJF (X-ray 2.10A ) 4H4B (X-ray 2.90A ) 5CQZ (X-ray 2.90A ) 5CR7 (X-ray 2.90A ) 5K7Y (X-ray 1.79A ) 5L4Z (X-ray 1.84A ) 5L50 (X-ray 1.64A ) 5OPK (X-ray 1.74A ) 5OPL (X-ray 1.80A ) 5OPM (X-ray 1.68A ) 5OPN (X-ray 1.77A ) 5OPO (X-ray 2.00A ) 5OPP (X-ray 1.70A ) 6DD3 (X-ray 1.98A ) 6DDB (X-ray 2.80A ) 6DDC (X-ray 2.91A ) 6DDH (X-ray 2.35A ) 6DDK (X-ray 2.50A ) 6DDL (X-ray 2.26A ) 6DDO (X-ray 2.48A ) 6DDQ (X-ray 2.31A ) 6DDX (X-ray 2.90A ) 6DDY (X-ray 1.80A ) 6DDZ (X-ray 1.97A ) 6DE0 (X-ray 2.05A ) 6DE1 (X-ray 2.15A ) 6DE2 (X-ray 2.10A ) 6DE3 (X-ray 3.06A ) 6FIR (X-ray 2.50A ) 6FIS (X-ray 2.30A ) 6FIU (X-ray 2.50A ) 6FIW (X-ray 2.20A ) 6FXH (X-ray 2.30A ) |
| DBSNP | rs10883841 rs12262171 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:9371705}. |
| Mouse PG classification | NA |
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