Gene Information
Gene NameNSG1
OrganismHomo sapiens (Human)
Gene Length185
Protein NamesNeuronal vesicle trafficking-associated protein 1 (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1)
Target NameNA
Target TypeNA
Gene Age645 ( ENSG00000168824 )
Evolutionary StageVertebrata
AlphaFoldDBP42857
Gene CardNSG1
Uniprot IDP42857
PfamPF06387
In ASDno
Allosteric Predictionno (-0.960168059)
Ortholog in AnimalsAlpaca_ NSG1 ( ortholog_one2one )
GuineaPig_ NSG1 ( ortholog_one2one )
Macaque_ NSG1 ( ortholog_one2one )
Mouse_ Nsg1 ( ortholog_one2one )
Pig_ NSG1 ( ortholog_one2one )
Rat_ Nsg1 ( ortholog_one2one )
OhnologsNA
ParalogsNSG2, CALY
Tissuebrain, ovary
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP NA 
Subcellular location [CC]Membrane {ECO:0000250|UniProtKB:P02683};
Single-pass type II membrane protein {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, trans-Golgi network membrane {ECO:0000250|UniProtKB:P02683}. Endosome membrane {ECO:0000250|UniProtKB:P02683}. Cell projection, dendrite {ECO:0000250|UniProtKB:P02683}. Early endosome membrane {ECO:0000250|UniProtKB:P02683}. Late endosome membrane {ECO:0000250|UniProtKB:P02683}. Lysosome lumen {ECO:0000250|UniProtKB:P02683}. Recycling endosome membrane {ECO:0000250|UniProtKB:P02683}. Cytoplasmic vesicle membrane {ECO:0000250|UniProtKB:P02683}. Golgi apparatus, Golgi stack membrane {ECO:0000250|UniProtKB:P02683}. Endosome, multivesicular body membrane {ECO:0000250|UniProtKB:P02683}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20599942}. Note=Endocytosed from the cell surface, thus enters into early endosomes, trafficks to late endosomes and degradates in lysosomes (By similarity). Endoplasmic reticulum targeting is essential for apoptosis (PubMed:20599942). Found in both stationary and motile endosomes. A previous study supports a type I membrane protein topology (By similarity). {ECO:0000250|UniProtKB:P02683, ECO:0000250|UniProtKB:Q62092, ECO:0000269|PubMed:20599942}.
Mouse PG classificationNA
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