| Gene Information | |
|---|---|
| Gene Name | NSDHL |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (EC 1.1.1.170) (Protein H105e3) |
| Target Name | sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000147383 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q15738 |
| Gene Card | NSDHL |
| Uniprot ID | Q15738 |
| Pfam | PF01073 |
| In ASD | no |
| Allosteric Prediction | no (-0.297669538) |
| Ortholog in Animals | Alpaca_ NSDHL ( ortholog_one2one ) Alpaca_ NSDHL ( ortholog_one2many ) Dog_ NSDHL ( ortholog_one2one ) GuineaPig_ NSDHL ( ortholog_one2one ) Macaque_ NSDHL ( ortholog_one2one ) Mouse_ Nsdhl ( ortholog_one2one ) Pig_ NSDHL ( ortholog_one2one ) Rat_ Nsdhl ( ortholog_one2one ) Rabbit_ NSDHL ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HSD3B7, GFUS, HSD3B2, HSD3B1, SDR42E2, GALE, SDR42E1, GMDS, TGDS, UXS1 |
| Tissue | NA |
| Tissue Specificity | Brain, heart, liver, lung, kidney, skin and placenta. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6JKG (X-ray 2.90A ) 6JKH (X-ray 3.00A ) |
| DBSNP | rs104894909 rs104894904 rs104894901 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:21129721}; Single-pass membrane protein {ECO:0000255}. Lipid droplet {ECO:0000250|UniProtKB:Q9R1J0}. Note=Trafficking through the Golgi is necessary for ER membrane localization. {ECO:0000250|UniProtKB:Q9R1J0}. |
| Mouse PG classification | LPG |
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