| Gene Information | |
|---|---|
| Gene Name | NSD1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2696 |
| Protein Names | Histone-lysine N-methyltransferase, H3 lysine-36 specific (EC 2.1.1.357) (Androgen receptor coactivator 267 kDa protein) (Androgen receptor-associated protein of 267 kDa) (H3-K36-HMTase) (Lysine N-methyltransferase 3B) (Nuclear receptor-binding SET domain-containing protein 1) (NR-binding SET domain-containing protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000165671 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96L73 |
| Gene Card | NSD1 |
| Uniprot ID | Q96L73 |
| Pfam | PF17907; PF17982; PF00855; PF00856 |
| In ASD | no |
| Allosteric Prediction | no (-0.643206802) |
| Ortholog in Animals | Alpaca_ NSD1 ( ortholog_one2one ) Dog_ NSD1 ( ortholog_one2one ) GuineaPig_ NSD1 ( ortholog_one2one ) Macaque_ NSD1 ( ortholog_one2one ) Mouse_ Nsd1 ( ortholog_one2one ) Pig_ NSD1 ( ortholog_one2one ) Rat_ Nsd1 ( ortholog_one2one ) Rabbit_ NSD1 ( ortholog_one2one ) |
| Ohnologs | NSD3 |
| Paralogs | KMT2B, ASH1L, NSD3, EHMT2, SUV39H1, EZH1, KMT2A, SETBP1, SETD2, SETD1B, SETD1A, SUV39H2, EHMT1, KMT2D, NSD2, SETDB2, EZH2, KMT2C, SETDB1 |
| Tissue | NA |
| Tissue Specificity | Expressed in the fetal/adult brain, kidney, skeletal muscle, spleen, and the thymus, and faintly in the lung. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3OOI (X-ray 1.75A ) 6KQP (X-ray 2.40A ) 6KQQ (X-ray 1.80A ) |
| DBSNP | rs3733875 rs28932177 rs28932178 rs28932179 rs35597015 rs587784169 rs797045825 rs587784174 rs587784177 rs587784176 rs121908068 rs121908069 rs35848863 rs34165241 |
| Subcellular location [CC] | Nucleus. Chromosome {ECO:0000305}. |
| Mouse PG classification | LPG |
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