| Gene Information | |
|---|---|
| Gene Name | PKD1L3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1732 |
| Protein Names | Polycystic kidney disease protein 1-like 3 (PC1-like 3 protein) (Polycystin-1L3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000277481 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q7Z443 |
| Gene Card | PKD1L3 |
| Uniprot ID | Q7Z443 |
| Pfam | PF01825; PF00059; PF08016; PF01477 |
| In ASD | no |
| Allosteric Prediction | yes (0.259930164) |
| Ortholog in Animals | Alpaca_ PKD1L3 ( ortholog_one2one ) Dog_ PKD1L3 ( ortholog_one2one ) Macaque_ PKD1L3 ( ortholog_one2one ) Mouse_ Pkd1l3 ( ortholog_one2one ) Rat_ Pkd1l3 ( ortholog_one2one ) Rabbit_ PKD1L3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PKDREJ, PKD1L2, PKD2L2, DENND5B, DENND5A, PKD2L1, LOXHD1, PKD1L1, PKD1, PKD2 |
| Tissue | NA |
| Tissue Specificity | Highly expressed in placenta, weakly in heart and lung. {ECO:0000269|PubMed:12782129}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs16973585 rs4788591 rs12708923 rs7185272 rs16973537 rs1559401 rs9925415 rs9921412 rs1035543 rs13335617 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:23212381}; Multi-pass membrane protein {ECO:0000269|PubMed:18535624, ECO:0000269|PubMed:20538909, ECO:0000269|PubMed:23212381}. Note=Interaction with PKD2L1 is required for localization to the cell membrane. |
| Mouse PG classification | NA |
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