| Gene Information | |
|---|---|
| Gene Name | NRP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 923 |
| Protein Names | Neuropilin-1 (Vascular endothelial cell growth factor 165 receptor) (CD antigen CD304) |
| Target Name | neuropilin-1 |
| Target Type | Successful target |
| Gene Age | 544 ( ENSG00000099250 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14786 |
| Gene Card | NRP1 |
| Uniprot ID | O14786 |
| Pfam | PF00431; PF11980; PF00754; PF00629 |
| In ASD | no |
| Allosteric Prediction | yes (0.142610412) |
| Ortholog in Animals | Alpaca_ NRP1 ( ortholog_one2one ) Dog_ NRP1 ( ortholog_one2one ) GuineaPig_ NRP1 ( ortholog_one2one ) Macaque_ NRP1 ( ortholog_one2one ) Mouse_ Nrp1 ( ortholog_one2one ) Pig_ NRP1 ( ortholog_one2one ) Rat_ Nrp1 ( ortholog_one2one ) Rabbit_ NRP1 ( ortholog_one2one ) |
| Ohnologs | NRP2 |
| Paralogs | CNTNAP3B, CNTNAP3, CNTNAP3C, CNTNAP4, PDGFD, ASTL, CNTNAP5, HEPH, MEP1A, NRXN2, CNTNAP2, MFRP, CUZD1, NETO2, TLL2, F5, PCOLCE, CP, NRXN3, EDIL3, CNTNAP1, CUBN, MEP1B, NETO1, MFGE8, PCOLCE2, NRP2, HEPHL1, F8, TLL1, NRXN1, DCBLD2, PDGFC, CDCP2, BMP1 |
| Tissue | NA |
| Tissue Specificity | [Isoform 1]: The expression of isoforms 1 and 2 does not seem to overlap. Expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain (PubMed:10688880, PubMed:9529250). Expressed in olfactory epithelium (at protein level) (PubMed:33082293). Expressed in the central nervous system, including olfactory related regions such as the olfactory tubercles and paraolfactory gyri (PubMed:33082293). {ECO:0000269|PubMed:10688880, ECO:0000269|PubMed:33082293, ECO:0000269|PubMed:9529250}.; [Isoform 2]: The expression of isoforms 1 and 2 does not seem to overlap. Found in liver hepatocytes, kidney distal and proximal tubules. {ECO:0000269|PubMed:10688880}. |
| Pharmacological Animal Models | 0.050380(Chimpanzee);0.055913(Mouse);0.003343(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1KEX (X-ray 1.90A ) 2QQI (X-ray 1.80A ) 2QQM (X-ray 2.00A ) 2QQN (X-ray 2.20A ) 3I97 (X-ray 2.90A ) 4DEQ (X-ray 2.65A ) 4RN5 (X-ray 1.73A ) 5C7G (X-ray 1.45A ) 5IJR (X-ray 1.52A ) 5IYY (X-ray 1.60A ) 5J1X (X-ray 2.10A ) 5JGI (X-ray 1.38A ) 5JGQ (X-ray 1.60A ) 5JHK (X-ray 1.80A ) 5L73 (X-ray 2.24A ) 6FMC (X-ray 0.90A ) 6FMF (X-ray 2.81A ) 6TKK (X-ray 1.06A ) 7JJC (X-ray 2.36A ) 7O1N (X-ray 1.56A ) 7P5U (X-ray 1.60A ) |
| DBSNP | rs7079053 rs2228637 rs2228638 |
| Subcellular location [CC] | [Isoform 2]: Secreted {ECO:0000269|PubMed:10688880}.; Mitochondrion membrane {ECO:0000305|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cell membrane {ECO:0000269|PubMed:30623799}; Single-pass type I membrane protein {ECO:0000255}. Cytoplasm {ECO:0000269|PubMed:30623799}. |
| Mouse PG classification | NA |
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