| Gene Information | |
|---|---|
| Gene Name | NRG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 720 |
| Protein Names | Pro-neuregulin-3, membrane-bound isoform (Pro-NRG3) [Cleaved into: Neuregulin-3 (NRG-3)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000185737 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P56975 |
| Gene Card | NRG3 |
| Uniprot ID | P56975 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.57047033) |
| Ortholog in Animals | Alpaca_ NRG3 ( ortholog_one2one ) Dog_ NRG3 ( ortholog_one2one ) GuineaPig_ NRG3 ( ortholog_one2one ) Macaque_ NRG3 ( ortholog_one2one ) Mouse_ Nrg3 ( ortholog_one2one ) Pig_ NRG3 ( ortholog_one2one ) Rat_ Nrg3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRG4, NRG1, NRG2 |
| Tissue | brain |
| Tissue Specificity | Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2295934 rs17101193 |
| Subcellular location [CC] | [Pro-neuregulin-3, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; [Neuregulin-3]: Secreted {ECO:0000250}.; [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=Isoform 3 is also proteolytically released as a soluble form. |
| Mouse PG classification | NA |
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