| Gene Information | |
|---|---|
| Gene Name | NRG2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 850 |
| Protein Names | Pro-neuregulin-2, membrane-bound isoform (Pro-NRG2) [Cleaved into: Neuregulin-2 (NRG-2) (Divergent of neuregulin-1) (DON-1) (Neural- and thymus-derived activator for ERBB kinases) (NTAK)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000158458 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O14511 |
| Gene Card | NRG2 |
| Uniprot ID | O14511 |
| Pfam | PF07679; PF02158 |
| In ASD | no |
| Allosteric Prediction | no (-0.082874712) |
| Ortholog in Animals | Alpaca_ NRG2 ( ortholog_one2one ) Dog_ NRG2 ( ortholog_one2one ) GuineaPig_ NRG2 ( ortholog_one2one ) Macaque_ NRG2 ( ortholog_one2one ) Mouse_ Nrg2 ( ortholog_one2one ) Pig_ NRG2 ( ortholog_one2one ) Rat_ Nrg2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NRG3, NRG4, NRG1 |
| Tissue | NA |
| Tissue Specificity | Restricted to the cerebellum in the adult. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | [Pro-neuregulin-2, membrane-bound isoform]: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Does not seem to be active. {ECO:0000250}.; [Neuregulin-2]: Secreted {ECO:0000250}. |
| Mouse PG classification | NA |
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