| Gene Information | |
|---|---|
| Gene Name | NRF2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 605 |
| Protein Names | Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (Nrf-2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q16236 |
| Gene Card | NFE2L2 |
| Uniprot ID | Q16236 |
| Pfam | PF03131 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle. {ECO:0000269|PubMed:7937919}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.009091(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2FLU (X-ray 1.50A ) 2LZ1 (NMR - ) 3ZGC (X-ray 2.20A ) 4IFL (X-ray 1.80A ) 5WFV (X-ray 1.91A ) 6T7V (X-ray 2.60A ) 7K28 (X-ray 2.15A ) 7K29 (X-ray 2.20A ) 7K2A (X-ray 1.90A ) 7K2B (X-ray 2.31A ) 7K2C (X-ray 2.11A ) 7K2D (X-ray 2.21A ) 7K2E (X-ray 2.03A ) 7K2K (X-ray 1.98A ) 7O7B (NMR - ) |
| DBSNP | rs1553488015 rs35248500 rs1057519922 rs1553487947 rs1553487942 rs5031039 rs34154613 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:21196497}. Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978, ECO:0000269|PubMed:11035812, ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:21196497, ECO:0000269|PubMed:29983246}. Note=Cytosolic under unstressed conditions: ubiquitinated and degraded by the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:15601839, PubMed:21196497). Translocates into the nucleus upon induction by electrophilic agents that inactivate the BCR(KEAP1) E3 ubiquitin ligase complex (PubMed:21196497). {ECO:0000269|PubMed:15601839, ECO:0000269|PubMed:21196497}. |
| Mouse PG classification | NA |
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