| Gene Information | |
|---|---|
| Gene Name | SH2B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 632 |
| Protein Names | SH2B adapter protein 2 (Adapter protein with pleckstrin homology and Src homology 2 domains) (SH2 and PH domain-containing adapter protein APS) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000160999 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O14492 |
| Gene Card | SH2B2 |
| Uniprot ID | O14492 |
| Pfam | PF00169; PF08916; PF00017 |
| In ASD | no |
| Allosteric Prediction | yes (0.870407048) |
| Ortholog in Animals | Alpaca_ SH2B2 ( ortholog_one2many ) Dog_ SH2B2 ( ortholog_one2one ) GuineaPig_ SH2B2 ( ortholog_one2one ) Macaque_ SH2B2 ( ortholog_one2one ) Mouse_ Sh2b2 ( ortholog_one2one ) Pig_ SH2B2 ( ortholog_one2one ) Rat_ Sh2b2 ( ortholog_one2one ) Rabbit_ SH2B2 ( ortholog_one2one ) |
| Ohnologs | SH2B3, SH2B1 |
| Paralogs | SH2B1, SH2B3 |
| Tissue | NA |
| Tissue Specificity | Expressed in spleen, prostate, testis, uterus, small intestine and skeletal muscle. Among hematopoietic cell lines, expressed exclusively in B-cells. Not expressed in most tumor cell lines. {ECO:0000269|PubMed:9233773, ECO:0000269|PubMed:9989826}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002419(Rat);0.022222(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1Q2H (X-ray 1.70A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9989826}. Cell membrane {ECO:0000269|PubMed:9989826}. Note=Cytoplasmic before PDGF stimulation. After PDGF stimulation, localized at the cell membrane and peripheral region. |
| Mouse PG classification | NA |
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