| Gene Information | |
|---|---|
| Gene Name | KIAA1303 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1335 |
| Protein Names | Regulatory-associated protein of mTOR (Raptor) (p150 target of rapamycin (TOR)-scaffold protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q8N122 |
| Gene Card | RPTOR |
| Uniprot ID | Q8N122 |
| Pfam | PF02985; PF14538; PF00400 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen. {ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12408816}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.102926(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5H64 (EM 4.40A ) 6BCU (EM 3.43A ) 6BCX (EM 3.00A ) 6SB0 (EM 5.50A ) 6SB2 (EM 6.20A ) 6U62 (EM 3.18A ) 7OWG (EM 4.70A ) 7PEA (EM 4.07A ) 7PEB (EM 3.67A ) 7PEC (EM 4.24A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm. Lysosome. Cytoplasmic granule {ECO:0000269|PubMed:25940091}. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased. |
| Mouse PG classification | NA |
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