Gene Information
Gene NameNR3C2
OrganismHomo sapiens (Human)
Gene Length984
Protein NamesMineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2)
Target Namemineralocorticoid receptor
Target TypeNA
Gene Age950 ( ENSG00000151623 )
Evolutionary StageVertebrata
AlphaFoldDBP08235
Gene CardNR3C2
Uniprot IDP08235
PfamPF00104; PF00105
In ASDno
Allosteric Predictionyes (1.163527107)
Ortholog in AnimalsAlpaca_ NR3C2 ( ortholog_one2one )
Dog_ NR3C2 ( ortholog_one2one )
GuineaPig_ NR3C2 ( ortholog_one2one )
Macaque_ NR3C2 ( ortholog_one2one )
Mouse_ Nr3c2 ( ortholog_one2one )
Pig_ NR3C2 ( ortholog_one2one )
Rat_ Nr3c2 ( ortholog_one2one )
Rabbit_ NR3C2 ( ortholog_one2one )
OhnologsPGR, NR3C1, AR
ParalogsESRRG, ESRRB, NR3C1, ESRRA, ESR1, AR, ESR2, PGR
TissueNA
Tissue SpecificityUbiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. {ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:9141514}.
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1Y9R  (X-ray  1.96A  1YA3  (X-ray  2.34A  2A3I  (X-ray  1.95A  2AA2  (X-ray  1.95A  2AA5  (X-ray  2.20A  2AA6  (X-ray  1.95A  2AA7  (X-ray  2.20A  2AAX  (X-ray  1.75A  2AB2  (X-ray  1.85A  2ABI  (X-ray  2.33A  2OAX  (X-ray  2.29A  3VHU  (X-ray  2.11A  3VHV  (X-ray  1.35A  3WFF  (X-ray  2.05A  3WFG  (X-ray  1.40A  4PF3  (X-ray  1.10A  4TNT  (X-ray  2.39A  4UDA  (X-ray  2.03A  4UDB  (X-ray  2.36A  5HCV  (X-ray  2.50A  5L7E  (X-ray  1.86A  5L7G  (X-ray  2.01A  5L7H  (X-ray  1.84A  5MWP  (X-ray  1.82A  5MWY  (X-ray  1.75A  6GEV  (X-ray  1.54A  6GG8  (X-ray  1.80A  6GGG  (X-ray  1.71A  6L88  (X-ray  3.00A 
DBSNP rs5522  rs5523  rs5526  rs5527  rs121912566  rs121912565  rs41511344  rs121912573  rs13306592  rs121912563  rs121912574  rs121912567 
Subcellular location [CC]Cytoplasm. Nucleus. Endoplasmic reticulum membrane;
Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand;
nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane.
Mouse PG classificationHPG
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