| Gene Information | |
|---|---|
| Gene Name | NR3C2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 984 |
| Protein Names | Mineralocorticoid receptor (MR) (Nuclear receptor subfamily 3 group C member 2) |
| Target Name | mineralocorticoid receptor |
| Target Type | Successful target |
| Gene Age | 950 ( ENSG00000151623 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P08235 |
| Gene Card | NR3C2 |
| Uniprot ID | P08235 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (1.163527107) |
| Ortholog in Animals | Alpaca_ NR3C2 ( ortholog_one2one ) Dog_ NR3C2 ( ortholog_one2one ) GuineaPig_ NR3C2 ( ortholog_one2one ) Macaque_ NR3C2 ( ortholog_one2one ) Mouse_ Nr3c2 ( ortholog_one2one ) Pig_ NR3C2 ( ortholog_one2one ) Rat_ Nr3c2 ( ortholog_one2one ) Rabbit_ NR3C2 ( ortholog_one2one ) |
| Ohnologs | PGR, NR3C1, AR |
| Paralogs | ESRRG, ESRRB, NR3C1, ESRRA, ESR1, AR, ESR2, PGR |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Highly expressed in distal tubules, convoluted tubules and cortical collecting duct in kidney, and in sweat glands. Detected at lower levels in cardiomyocytes, in epidermis and in colon enterocytes. {ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:9141514}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1Y9R (X-ray 1.96A ) 1YA3 (X-ray 2.34A ) 2A3I (X-ray 1.95A ) 2AA2 (X-ray 1.95A ) 2AA5 (X-ray 2.20A ) 2AA6 (X-ray 1.95A ) 2AA7 (X-ray 2.20A ) 2AAX (X-ray 1.75A ) 2AB2 (X-ray 1.85A ) 2ABI (X-ray 2.33A ) 2OAX (X-ray 2.29A ) 3VHU (X-ray 2.11A ) 3VHV (X-ray 1.35A ) 3WFF (X-ray 2.05A ) 3WFG (X-ray 1.40A ) 4PF3 (X-ray 1.10A ) 4TNT (X-ray 2.39A ) 4UDA (X-ray 2.03A ) 4UDB (X-ray 2.36A ) 5HCV (X-ray 2.50A ) 5L7E (X-ray 1.86A ) 5L7G (X-ray 2.01A ) 5L7H (X-ray 1.84A ) 5MWP (X-ray 1.82A ) 5MWY (X-ray 1.75A ) 6GEV (X-ray 1.54A ) 6GG8 (X-ray 1.80A ) 6GGG (X-ray 1.71A ) 6L88 (X-ray 3.00A ) |
| DBSNP | rs5522 rs5523 rs5526 rs5527 rs121912566 rs121912565 rs41511344 rs121912573 rs13306592 rs121912563 rs121912574 rs121912567 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Cytoplasmic and nuclear in the absence of ligand; nuclear after ligand-binding. When bound to HSD11B2, it is found associated with the endoplasmic reticulum membrane. |
| Mouse PG classification | HPG |
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