| Gene Information | |
|---|---|
| Gene Name | NR2E3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 410 |
| Protein Names | Photoreceptor-specific nuclear receptor (Nuclear receptor subfamily 2 group E member 3) (Retina-specific nuclear receptor) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000278570 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y5X4 |
| Gene Card | NR2E3 |
| Uniprot ID | Q9Y5X4 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | no (-0.586517375) |
| Ortholog in Animals | Alpaca_ NR2E3 ( ortholog_one2one ) Dog_ NR2E3 ( ortholog_one2one ) GuineaPig_ NR2E3 ( ortholog_one2one ) Macaque_ NR2E3 ( ortholog_one2one ) Mouse_ Nr2e3 ( ortholog_one2one ) Pig_ NR2E3 ( ortholog_one2one ) Rat_ Nr2e3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | RXRB, NR2F2, RXRA, HNF4A, NR2F6, HNF4G, RXRG, NR2C2, NR2C1, NR2F1, NR2E1 |
| Tissue | NA |
| Tissue Specificity | Eye specific; found solely in the outer nuclear layer of the adult neurosensory retina, where the nuclei of cone and rod photoreceptors reside. {ECO:0000269|PubMed:15689355}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4LOG (X-ray 2.70A ) |
| DBSNP | rs202098481 rs121912631 rs104894493 rs104894492 rs1278137915 rs1489149705 rs766096417 rs990307718 rs146403122 rs1805020 rs1805021 rs1805023 rs377257254 rs2054201996 rs764901119 rs1805025 rs774102273 rs28937873 rs752883545 rs766769900 rs1303613101 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:15689355}. |
| Mouse PG classification | HPG |
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