Gene Information
Gene NameDGKI
OrganismHomo sapiens (Human)
Gene Length1065
Protein NamesDiacylglycerol kinase iota (DAG kinase iota) (DGK-iota) (EC 2.7.1.107)
Target Namediacylglycerol kinase
Target TypeNA
Gene Age987 ( ENSG00000157680 )
Evolutionary StageEukaryota
AlphaFoldDBO75912
Gene CardDGKI
Uniprot IDO75912
PfamPF12796; PF00130; PF00609; PF00781
In ASDno
Allosteric Predictionno (-0.210276203)
Ortholog in AnimalsAlpaca_ DGKI ( ortholog_one2one )
Dog_ CREB3L2 ( ortholog_one2one )
GuineaPig_ DGKI ( ortholog_one2one )
Macaque_ DGKI ( ortholog_one2one )
Mouse_ Dgki ( ortholog_one2one )
Pig_ DGKI ( ortholog_one2one )
Rat_ Dgki ( ortholog_one2one )
Rabbit_ DGKI ( ortholog_one2one )
OhnologsDGKZ
ParalogsDGKQ, DGKE, DGKG, DGKH, DGKB, DGKD, DGKA, DGKK, DGKZ
Tissuethyroid
Tissue SpecificitySpecifically expressed in brain and retina (PubMed:9830018). In brain, highly expressed in hippocampus, caudate nucleus, occipital pole, cerebral cortex, and cerebellum (PubMed:9830018). Also detected in kidney (PubMed:15894621). {ECO:0000269|PubMed:15894621, ECO:0000269|PubMed:9830018}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB NA 
DBSNP rs61757580 
Subcellular location [CC]Cell projection, axon {ECO:0000250|UniProtKB:F1MAB7}. Cell projection, dendrite {ECO:0000250|UniProtKB:F1MAB7}. Presynapse {ECO:0000250|UniProtKB:F1MAB7}. Postsynapse {ECO:0000250|UniProtKB:F1MAB7}. Postsynaptic density {ECO:0000250|UniProtKB:F1MAB7}. Synaptic cell membrane {ECO:0000250|UniProtKB:F1MAB7}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:F1MAB7}. Cytoplasm, cytosol {ECO:0000269|PubMed:9830018}. Nucleus {ECO:0000269|PubMed:9830018}. Note=Excluded from inhibitory synapses (By similarity). Localization between cytoplasm and nucleus is regulated by protein kinase C (PubMed:9830018). Both in the detergent soluble and particulate fractions (By similarity). {ECO:0000250|UniProtKB:F1MAB7, ECO:0000269|PubMed:9830018}.
Mouse PG classificationNA
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