| Gene Information | |
|---|---|
| Gene Name | NR1H3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 447 |
| Protein Names | Oxysterols receptor LXR-alpha (Liver X receptor alpha) (Nuclear receptor subfamily 1 group H member 3) |
| Target Name | oxysterols receptor lxr-alpha |
| Target Type | NA |
| Gene Age | 454 ( ENSG00000025434 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13133 |
| Gene Card | NR1H3 |
| Uniprot ID | Q13133 |
| Pfam | PF00104; PF00105 |
| In ASD | yes |
| Allosteric Prediction | yes (1.064582064) |
| Ortholog in Animals | Alpaca_ NR1H3 ( ortholog_one2one ) Dog_ NR1H3 ( ortholog_one2one ) GuineaPig_ NR1H3 ( ortholog_one2one ) Macaque_ NR1H3 ( ortholog_one2one ) Mouse_ Nr1h3 ( ortholog_one2one ) Pig_ NR1H3 ( ortholog_one2one ) Rat_ Nr1h3 ( ortholog_one2one ) Rabbit_ NR1H3 ( ortholog_one2one ) |
| Ohnologs | NR1H2 |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA |
| Tissue | NA |
| Tissue Specificity | Visceral organs specific expression. Strong expression was found in liver, kidney and intestine followed by spleen and to a lesser extent the adrenals. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1UHL (X-ray 2.90A ) 3IPQ (X-ray 2.00A ) 3IPS (X-ray 2.26A ) 3IPU (X-ray 2.40A ) 5AVI (X-ray 2.70A ) 5AVL (X-ray 2.80A ) 5HJS (X-ray 1.72A ) |
| DBSNP | rs41481445 |
| Subcellular location [CC] | Nucleus {ECO:0000255|PROSITE-ProRule:PRU00407, ECO:0000269|PubMed:25661920}. Cytoplasm {ECO:0000250|UniProtKB:Q9Z0Y9}. |
| Mouse PG classification | NA |
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