| Gene Information | |
|---|---|
| Gene Name | ARL3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 182 |
| Protein Names | ADP-ribosylation factor-like protein 3 |
| Target Name | adp-ribosylation factor-like protein 3 |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000138175 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P36405 |
| Gene Card | ARL3 |
| Uniprot ID | P36405 |
| Pfam | PF00025 |
| In ASD | no |
| Allosteric Prediction | no (-0.526260795) |
| Ortholog in Animals | Alpaca_ ARL3 ( ortholog_one2one ) Dog_ ARL3 ( ortholog_one2one ) GuineaPig_ ARL3 ( ortholog_one2one ) Macaque_ ARL3 ( ortholog_one2one ) Mouse_ Arl3 ( ortholog_one2one ) Pig_ ARL3 ( ortholog_one2one ) Rat_ Arl3 ( ortholog_one2one ) Rabbit_ ARL3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | ARL5C, ARF4, ARL10, ARL16, ARL2, ARFRP1, ARL17B, ARL17A, ARF3, ARF1, ARL1, ARL8B, TRIM23, ARL4D, ARL9, ARL14, ARL4A, ARL6, ARL13B, ARL13A, ARL15, ARL11, ARL5A, ARF5, ARL8A, SAR1B, ARF6, ARL4C, ARL5B, SAR1A |
| Tissue | NA |
| Tissue Specificity | Expressed in the retina. Strongly expressed in connecting cilium, the myoid region of the inner segments (IS) and in cone photoreceptors (at protein level). {ECO:0000269|PubMed:12417528}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.142857(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1141895 rs1564730440 rs776901858 rs770782663 |
| Subcellular location [CC] | Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Cell projection, cilium {ECO:0000269|PubMed:30269812}. Note=Detected predominantly in the photoreceptor connecting cilium. Present on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules. |
| Mouse PG classification | NA |
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