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Gene Information
Gene Name
NR1F3
Organism
Homo sapiens (Human)
Gene Length
518
Protein Names
Nuclear receptor ROR-gamma (Nuclear receptor RZR-gamma) (Nuclear receptor subfamily 1 group F member 3) (RAR-related orphan receptor C) (Retinoid-related orphan receptor-gamma)
Target Name
NA
Target Type
NA
Gene Age
NA
Evolutionary Stage
NA
AlphaFoldDB
P51449
Gene Card
RORC
Uniprot ID
P51449
Pfam
PF00104; PF00105
In ASD
yes
Allosteric Prediction
NA
Ortholog in Animals
NA
Ohnologs
NA
Paralogs
NA
Tissue
NA
Tissue Specificity
Isoform 1 is widely expressed in many tissues, including liver and adipose, and highly expressed in skeletal muscle. Isoform 2 is primarily expressed in immature thymocytes.
Pharmacological Animal Models
NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.133333(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB
3B0W
(X-ray
2.20A
)
3KYT
(X-ray
2.35A
)
3L0J
(X-ray
2.40A
)
3L0L
(X-ray
1.74A
)
4NB6
(X-ray
2.85A
)
4NIE
(X-ray
2.01A
)
4QM0
(X-ray
2.20A
)
4S14
(X-ray
3.54A
)
4WLB
(X-ray
1.70A
)
4WPF
(X-ray
2.20A
)
4WQP
(X-ray
1.99A
)
4XT9
(X-ray
2.25A
)
4YMQ
(X-ray
2.00A
)
4YPQ
(X-ray
2.32A
)
4ZJR
(X-ray
2.70A
)
4ZJW
(X-ray
2.50A
)
4ZOM
(X-ray
2.27A
)
5APH
(X-ray
1.54A
)
5APJ
(X-ray
2.08A
)
5APK
(X-ray
2.10A
)
5AYG
(X-ray
2.60A
)
5C4O
(X-ray
2.24A
)
5C4S
(X-ray
2.23A
)
5C4T
(X-ray
1.77A
)
5C4U
(X-ray
2.08A
)
5EJV
(X-ray
2.58A
)
5ETH
(X-ray
2.80A
)
5G42
(X-ray
1.72A
)
5G43
(X-ray
2.58A
)
5G44
(X-ray
1.84A
)
5G45
(X-ray
2.07A
)
5G46
(X-ray
1.76A
)
5IXK
(X-ray
2.35A
)
5IZ0
(X-ray
2.63A
)
5K38
(X-ray
2.05A
)
5K3L
(X-ray
2.75A
)
5K3M
(X-ray
2.89A
)
5K3N
(X-ray
2.67A
)
5K6E
(X-ray
2.80A
)
5K74
(X-ray
2.75A
)
5LWP
(X-ray
2.40A
)
5M96
(X-ray
1.77A
)
5NI5
(X-ray
2.30A
)
5NI7
(X-ray
2.45A
)
5NI8
(X-ray
1.94A
)
5NIB
(X-ray
1.82A
)
5NTI
(X-ray
2.40A
)
5NTK
(X-ray
1.90A
)
5NTN
(X-ray
1.90A
)
5NTP
(X-ray
1.70A
)
5NTQ
(X-ray
2.26A
)
5NTW
(X-ray
1.64A
)
5NU1
(X-ray
1.85A
)
5UFO
(X-ray
2.80A
)
5UFR
(X-ray
2.07A
)
5UHI
(X-ray
3.20A
)
5VB3
(X-ray
1.95A
)
5VB5
(X-ray
2.23A
)
5VB6
(X-ray
2.04A
)
5VB7
(X-ray
2.33A
)
5VQK
(X-ray
3.10A
)
5VQL
(X-ray
2.70A
)
5W4R
(X-ray
3.00A
)
5W4V
(X-ray
2.65A
)
5X8Q
(X-ray
2.20A
)
5YP5
(X-ray
2.65A
)
5YP6
(X-ray
2.20A
)
5ZA1
(X-ray
2.52A
)
6A22
(X-ray
2.55A
)
6B30
(X-ray
2.69A
)
6B31
(X-ray
3.18A
)
6B33
(X-ray
2.48A
)
6BN6
(X-ray
2.40A
)
6BR2
(X-ray
3.18A
)
6BR3
(X-ray
3.00A
)
6CN5
(X-ray
2.30A
)
6CN6
(X-ray
2.45A
)
6CVH
(X-ray
3.50A
)
6E3E
(X-ray
2.47A
)
6E3G
(X-ray
2.10A
)
6ESN
(X-ray
1.84A
)
6FGQ
(X-ray
2.37A
)
6FZU
(X-ray
1.80A
)
6G05
(X-ray
1.90A
)
6G07
(X-ray
1.66A
)
6IVX
(X-ray
2.35A
)
6J1L
(X-ray
2.30A
)
6J3N
(X-ray
1.99A
)
6LO9
(X-ray
1.86A
)
6LOA
(X-ray
2.50A
)
6LOB
(X-ray
2.40A
)
6LOC
(X-ray
2.20A
)
6NAD
(X-ray
2.90A
)
6NWS
(X-ray
2.44A
)
6NWT
(X-ray
2.35A
)
6NWU
(X-ray
3.20A
)
6O3Z
(X-ray
2.40A
)
6O98
(X-ray
2.29A
)
6P9F
(X-ray
2.80A
)
6Q2W
(X-ray
1.99A
)
6Q6M
(X-ray
2.35A
)
6Q6O
(X-ray
2.30A
)
6Q7A
(X-ray
2.20A
)
6Q7H
(X-ray
2.30A
)
6R7A
(X-ray
2.13A
)
6R7J
(X-ray
1.84A
)
6R7K
(X-ray
1.54A
)
6SAL
(X-ray
1.61A
)
6SLZ
(X-ray
2.20A
)
6T4G
(X-ray
1.93A
)
6T4I
(X-ray
1.84A
)
6T4J
(X-ray
1.79A
)
6T4K
(X-ray
1.89A
)
6T4T
(X-ray
1.62A
)
6T4U
(X-ray
2.00A
)
6T4W
(X-ray
1.71A
)
6T4X
(X-ray
1.48A
)
6T4Y
(X-ray
1.95A
)
6T50
(X-ray
1.87A
)
6TLM
(X-ray
2.32A
)
6TLQ
(X-ray
1.76A
)
6TLT
(X-ray
2.11A
)
6U25
(X-ray
2.61A
)
6UCG
(X-ray
2.87A
)
6VQF
(X-ray
2.00A
)
6VSW
(X-ray
3.20A
)
6W9H
(X-ray
2.00A
)
6W9I
(X-ray
1.61A
)
6XAE
(X-ray
2.26A
)
6XFV
(X-ray
2.15A
)
7E3M
(X-ray
2.80A
)
7JH2
(X-ray
2.37A
)
7JTM
(X-ray
2.43A
)
7JTW
(X-ray
1.90A
)
7JYM
(X-ray
3.05A
)
7KCO
(X-ray
1.86A
)
7KQJ
(X-ray
2.65A
)
7KXD
(X-ray
1.62A
)
7KXE
(X-ray
2.42A
)
7KXF
(X-ray
2.14A
)
7LUK
(X-ray
2.09A
)
7NEC
(X-ray
1.95A
)
7NP5
(X-ray
1.55A
)
7NP6
(X-ray
1.84A
)
7NPC
(X-ray
1.47A
)
7OFI
(X-ray
1.95A
)
7OFK
(X-ray
1.61A
)
DBSNP
rs774357869
Subcellular location [CC]
Nucleus {ECO:0000269|PubMed:26160376}.
Mouse PG classification
NA
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