| Gene Information | |
|---|---|
| Gene Name | NR0B2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 257 |
| Protein Names | Nuclear receptor subfamily 0 group B member 2 (Orphan nuclear receptor SHP) (Small heterodimer partner) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000131910 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q15466 |
| Gene Card | NR0B2 |
| Uniprot ID | Q15466 |
| Pfam | PF00104 |
| In ASD | no |
| Allosteric Prediction | yes (0.549596653) |
| Ortholog in Animals | Alpaca_ NR0B2 ( ortholog_one2one ) Dog_ NR0B2 ( ortholog_one2one ) GuineaPig_ NR0B2 ( ortholog_one2one ) Macaque_ NR0B2 ( ortholog_one2one ) Mouse_ Nr0b2 ( ortholog_one2one ) Pig_ NR0B2 ( ortholog_one2one ) Rat_ Nr0b2 ( ortholog_one2one ) Rabbit_ NR0B2 ( ortholog_one2one ) |
| Ohnologs | NR0B1 |
| Paralogs | NR0B1 |
| Tissue | left.atrium, pancreas, liver |
| Tissue Specificity | Liver. Low levels of expression were detected in heart and pancreas. {ECO:0000269|PubMed:8650544}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001942(Rat);0.028571(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1YUC (X-ray 1.90A ) 2Q3Y (X-ray 2.40A ) 2Z4J (X-ray 2.60A ) 4DOR (X-ray 1.90A ) 4ONI (X-ray 1.80A ) 5UFS (X-ray 2.12A ) 6W9M (X-ray 1.59A ) |
| DBSNP | rs777291973 rs6659176 rs202154574 rs74315350 rs199976415 rs200475847 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:14752053, ECO:0000269|PubMed:28797635}. Cytoplasm {ECO:0000269|PubMed:14752053}. Note=Colocalizes with NEUROD1 in the nucleus. |
| Mouse PG classification | LPG |
| click here to return to the previous page | |