| Gene Information | |
|---|---|
| Gene Name | NQO1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 274 |
| Protein Names | NAD(P)H dehydrogenase [quinone] 1 (EC 1.6.5.2) (Azoreductase) (DT-diaphorase) (DTD) (Menadione reductase) (NAD(P)H:quinone oxidoreductase 1) (Phylloquinone reductase) (Quinone reductase 1) (QR1) |
| Target Name | quinone reductase 1 |
| Target Type | Clinical trial target |
| Gene Age | 454 ( ENSG00000181019 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P15559 |
| Gene Card | NQO1 |
| Uniprot ID | P15559 |
| Pfam | PF02525 |
| In ASD | yes |
| Allosteric Prediction | yes (0.38908248) |
| Ortholog in Animals | Alpaca_ NQO1 ( ortholog_one2one ) Dog_ NQO1 ( ortholog_one2one ) GuineaPig_ NQO1 ( ortholog_one2one ) Macaque_ NQO1 ( ortholog_one2one ) Mouse_ Nqo1 ( ortholog_one2one ) Pig_ NQO1 ( ortholog_one2one ) Rat_ Nqo1 ( ortholog_one2one ) Rabbit_ NQO1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NQO2 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1D4A (X-ray 1.70A ) 1DXO (X-ray 2.50A ) 1GG5 (X-ray 2.50A ) 1H66 (X-ray 2.00A ) 1H69 (X-ray 1.86A ) 1KBO (X-ray 2.30A ) 1KBQ (X-ray 1.80A ) 1QBG (X-ray 2.30A ) 2F1O (X-ray 2.75A ) 3JSX (X-ray 2.45A ) 4CET (X-ray 2.20A ) 4CF6 (X-ray 2.69A ) 5A4K (X-ray 2.09A ) 5EA2 (X-ray 2.01A ) 5EAI (X-ray 2.90A ) 5FUQ (X-ray 2.04A ) 6FY4 (X-ray 2.76A ) 6LLC (X-ray 2.50A ) |
| DBSNP | rs1131341 rs1800566 rs34447156 |
| Subcellular location [CC] | Cytoplasm, cytosol {ECO:0000250|UniProtKB:P05982}. |
| Mouse PG classification | NA |
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