| Gene Information | |
|---|---|
| Gene Name | NPY4R |
| Organism | Homo sapiens (Human) |
| Gene Length | 375 |
| Protein Names | Neuropeptide Y receptor type 4 (NPY4-R) (Pancreatic polypeptide receptor 1) (PP1) |
| Target Name | neuropeptide y receptor type 4 |
| Target Type | Clinical trial target |
| Gene Age | 544 ( ENSG00000204174 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P50391 |
| Gene Card | NPY4R |
| Uniprot ID | P50391 |
| Pfam | PF00001 |
| In ASD | yes |
| Allosteric Prediction | yes (1.150904994) |
| Ortholog in Animals | Alpaca_ NPY4R ( ortholog_one2many ) GuineaPig_ Ppyr1 ( ortholog_one2many ) Mouse_ Npy4r ( ortholog_one2many ) Rat_ Npy4r ( ortholog_one2many ) Rabbit_ NPY4R ( ortholog_one2many ) |
| Ohnologs | GPR83, NPY1R |
| Paralogs | TACR2, OR9A2, NPY1R, MTNR1B, OR11H6, OR11H7, OR11H4, OR9A1P, OR9G1, NPY2R, MTNR1A, GPR50, GPR75, OR11G2, MCHR2, MCHR1, GPR19, OR11A1, TACR1, TACR3, OR11H2, OR11H12, OR11H1, GPR83, PROKR2, PROKR1, GPR88, PRLHR, OR51F1, OR10X1, NPY5R, OR9A4, NPY4R2 |
| Tissue | NA |
| Tissue Specificity | Highest levels found in brain, coronary artery and ileum. Low levels in pancreas and kidney. Detected in colon and small intestine. {ECO:0000269|PubMed:7493937, ECO:0000269|PubMed:7592911}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7X9C (EM 3.00A ) |
| DBSNP | rs2229967 rs3824733 |
| Subcellular location [CC] | Cell membrane {ECO:0000305|PubMed:7592911}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |