| Gene Information | |
|---|---|
| Gene Name | NPTN |
| Organism | Homo sapiens (Human) |
| Gene Length | 398 |
| Protein Names | Neuroplastin (Stromal cell-derived receptor 1) (SDR-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000156642 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y639 |
| Gene Card | NPTN |
| Uniprot ID | Q9Y639 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.443288657) |
| Ortholog in Animals | Alpaca_ NPTN ( ortholog_one2one ) Dog_ NPTN ( ortholog_one2one ) GuineaPig_ NPTN ( ortholog_one2one ) Macaque_ NPTN ( ortholog_one2one ) Mouse_ Nptn ( ortholog_one2one ) Pig_ NPTN ( ortholog_one2one ) Rat_ Nptn ( ortholog_one2one ) Rabbit_ NPTN ( ortholog_one2one ) |
| Ohnologs | BSG |
| Paralogs | EMB, BSG, VSTM2L |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is ubiquitously expressed. Isoform 2 is expressed in brain cortex and cerebellum (at protein level). {ECO:0000269|PubMed:17196182, ECO:0000269|Ref.1}. |
| Pharmacological Animal Models | 0.000730(Chimpanzee);NULL(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 6A69 (EM 4.11A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane {ECO:0000250|UniProtKB:P97546}; Single-pass type I membrane protein {ECO:0000250|UniProtKB:P97546}.; [Isoform 2]: Postsynaptic density {ECO:0000250|UniProtKB:P97546}. |
| Mouse PG classification | NA |
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