| Gene Information | |
|---|---|
| Gene Name | RET |
| Organism | Homo sapiens (Human) |
| Gene Length | 1114 |
| Protein Names | Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment] |
| Target Name | proto-oncogene tyrosine-protein kinase receptor ret |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000165731 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P07949 |
| Gene Card | RET |
| Uniprot ID | P07949 |
| Pfam | PF00028; PF07714; PF17756; PF17812; PF17813 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999929564) |
| Ortholog in Animals | Alpaca_ RET ( ortholog_one2one ) Dog_ RET ( ortholog_one2one ) GuineaPig_ RET ( ortholog_one2one ) Macaque_ RET ( ortholog_one2one ) Mouse_ Ret ( ortholog_one2one ) Pig_ RET ( ortholog_one2one ) Rat_ Ret ( ortholog_one2one ) Rabbit_ RET ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | EPHA7, NTRK1, EPHB3, ALK, FGFR3, EPHA2, LMTK2, EPHB1, EPHA3, INSR, PDGFRA, EGFR, CSF1R, ERBB3, KIT, NTRK3, DDR1, ERBB4, EPHA8, TEK, MUSK, MERTK, FGFR4, FLT3, EPHB6, FLT1, DDR2, EPHA6, NTRK2, IGF1R, INSRR, EPHB4, PDGFRB, ERBB2, KDR, EPHA5, FGFR2, TYRO3, MST1R, AXL, EPHB2, ROR1, ROR2, ROS1, EPHA10, EPHA4, LTK, FLT4, TIE1, FGFR1, RYK, EPHA1, MET |
| Tissue | adrenal.gland |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002202(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2IVS (X-ray 2.00A ) 2IVT (X-ray 2.60A ) 2IVU (X-ray 2.50A ) 2IVV (X-ray 2.25A ) 2X2K (X-ray 2.60A ) 2X2L (X-ray 2.00A ) 2X2M (X-ray 2.50A ) 2X2U (X-ray 2.00A ) 4CKI (X-ray 2.12A ) 4CKJ (X-ray 1.65A ) 4UX8 (EM 24.00A ) 5AMN (X-ray 2.57A ) 5FM2 (X-ray 3.30A ) 5FM3 (X-ray 2.95A ) 6FEK (X-ray 2.30A ) 6GL7 (EM 6.30A ) 6I82 (X-ray 2.05A ) 6I83 (X-ray 1.88A ) 6NE7 (X-ray 1.99A ) 6NEC (X-ray 1.87A ) 6NJA (X-ray 1.92A ) 6Q2J (EM 4.10A ) 6Q2N (EM 4.40A ) 6Q2O (EM 3.65A ) 6Q2R (EM 4.30A ) 6Q2S (EM 3.80A ) 6VHG (X-ray 2.30A ) 7DU8 (X-ray 2.75A ) 7DU9 (X-ray 2.31A ) 7DUA (X-ray 1.64A ) 7JU5 (X-ray 1.90A ) 7JU6 (X-ray 2.06A ) 7NZN (X-ray 2.39A ) 7RUN (X-ray 3.51A ) |
| DBSNP | rs76764689 rs77596424 rs192489011 rs1477699803 rs747483905 rs76397662 rs1588863999 rs149403911 rs76736111 rs79661516 rs562449603 rs541929171 rs35118262 rs1564491460 rs34682185 rs77702891 rs1060499894 rs80236571 rs774829203 rs762472027 rs78098482 rs183729115 rs1554818362 rs746970700 rs767601598 rs552057730 rs138624658 rs537874538 rs9282834 rs1483605155 rs377767393 rs77558292 rs77558292 rs377767396 rs77939446 rs377767391 rs377767391 rs377767391 rs80069458 rs377767397 rs79781594 rs76262710 rs76262710 rs79781594 rs79781594 rs77503355 rs77316810 rs77316810 rs77503355 rs79890926 rs77503355 rs1255575160 rs377767405 rs377767405 rs377767405 rs121913308 rs377767408 rs75996173 rs75076352 rs75076352 rs75076352 rs77709286 rs75996173 rs78935588 rs1799939 rs141185224 rs34288963 rs75075748 rs78014899 rs75686697 rs587778656 rs75030001 rs77724903 rs79658334 rs79658334 rs1318733775 rs34617196 rs200127630 rs55947360 rs1451004715 rs377767429 rs75234356 rs76087194 rs377767430 rs74799832 rs377767432 rs377767432 rs76534745 rs17158558 rs79853121 rs79853121 rs1490712863 rs1564501947 rs536486113 rs587778659 rs149513065 rs775583354 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:19823924, ECO:0000269|PubMed:21994944, ECO:0000269|PubMed:23333276, ECO:0000269|PubMed:28953886}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Endosome membrane {ECO:0000269|PubMed:19823924, ECO:0000269|PubMed:23333276}; Single-pass type I membrane protein {ECO:0000269|PubMed:19823924}. Note=Predominantly located on the plasma membrane. In the presence of SORL1 and GFRA1, directed to endosomes. {ECO:0000269|PubMed:23333276}. |
| Mouse PG classification | NA |
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