| Gene Information | |
|---|---|
| Gene Name | PARPBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 579 |
| Protein Names | PCNA-interacting partner (PARI) (PARP-1 binding protein) (PARP1-binding protein) (PARPBP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000185480 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9NWS1 |
| Gene Card | PARPBP |
| Uniprot ID | Q9NWS1 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | no (-0.938956104) |
| Ortholog in Animals | Alpaca_ PARPBP ( ortholog_one2one ) Dog_ PARPBP ( ortholog_one2one ) GuineaPig_ PARPBP ( ortholog_one2one ) Macaque_ PARPBP ( ortholog_one2one ) Mouse_ Parpbp ( ortholog_one2one ) Pig_ PARPBP ( ortholog_one2one ) Rat_ Parpbp ( ortholog_one2one ) Rabbit_ PARPBP ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Restricted to testis. Overexpressed in multiple cancer cells. {ECO:0000269|PubMed:20931645}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs12227879 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:20931645, ECO:0000269|PubMed:22153967}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA. |
| Mouse PG classification | NA |
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