| Gene Information | |
|---|---|
| Gene Name | NPRL2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 380 |
| Protein Names | GATOR complex protein NPRL2 (Gene 21 protein) (G21 protein) (Nitrogen permease regulator 2-like protein) (NPR2-like protein) (Tumor suppressor candidate 4) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000114388 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WTW4 |
| Gene Card | NPRL2 |
| Uniprot ID | Q8WTW4 |
| Pfam | PF06218 |
| In ASD | no |
| Allosteric Prediction | yes (0.030037103) |
| Ortholog in Animals | Alpaca_ NPRL2 ( ortholog_one2one ) Dog_ NPRL2 ( ortholog_one2one ) GuineaPig_ NPRL2 ( ortholog_one2one ) Macaque_ NPRL2 ( ortholog_one2one ) Mouse_ Nprl2 ( ortholog_one2one ) Pig_ NPRL2 ( ortholog_one2one ) Rat_ Nprl2 ( ortholog_one2one ) Rabbit_ NPRL2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888). Expressed in most lung cancer cell lines tested. {ECO:0000269|PubMed:26505888, ECO:0000269|PubMed:27173016}. |
| Pharmacological Animal Models | 0.029547(Chimpanzee);0.066557(Mouse);0.061010(Rat);0.093582(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6CES (EM 4.00A ) 6CET (EM 4.40A ) 7T3A (EM 4.00A ) 7T3B (EM 3.90A ) 7T3C (EM 4.00A ) |
| DBSNP | rs886037965 rs745518585 rs149128231 |
| Subcellular location [CC] | Lysosome membrane {ECO:0000269|PubMed:28199306}. Note=Localization to lysosomes is amino acid-independent. {ECO:0000269|PubMed:28199306}. |
| Mouse PG classification | NA |
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