| Gene Information | |
|---|---|
| Gene Name | DHCR24 |
| Organism | Homo sapiens (Human) |
| Gene Length | 516 |
| Protein Names | Delta(24)-sterol reductase (EC 1.3.1.72) (24-dehydrocholesterol reductase) (3-beta-hydroxysterol Delta-24-reductase) (Diminuto/dwarf1 homolog) (Seladin-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1488 ( ENSG00000116133 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q15392 |
| Gene Card | DHCR24 |
| Uniprot ID | Q15392 |
| Pfam | PF01565 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999555648) |
| Ortholog in Animals | Alpaca_ DHCR24 ( ortholog_one2one ) Dog_ DHCR24 ( ortholog_one2one ) GuineaPig_ DHCR24 ( ortholog_one2one ) Macaque_ DHCR24 ( ortholog_one2one ) Mouse_ Dhcr24 ( ortholog_one2one ) Pig_ DHCR24 ( ortholog_one2one ) Rat_ Dhcr24 ( ortholog_one2one ) Rabbit_ DHCR24 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex. {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:11519011}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.1(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs387906939 rs119475041 rs281797257 rs281797256 rs28939092 rs387906940 |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000269|PubMed:11007892, ECO:0000269|PubMed:22010141}; Single-pass membrane protein {ECO:0000255}. Golgi apparatus membrane {ECO:0000269|PubMed:11007892}; Single-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | LPG |
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