| Gene Information | |
|---|---|
| Gene Name | NPR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1047 |
| Protein Names | Atrial natriuretic peptide receptor 2 (EC 4.6.1.2) (Atrial natriuretic peptide receptor type B) (ANP-B) (ANPR-B) (NPR-B) (Guanylate cyclase B) (GC-B) |
| Target Name | atrial natriuretic peptide receptor 2 |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000159899 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P20594 |
| Gene Card | NPR2 |
| Uniprot ID | P20594 |
| Pfam | PF01094; PF00211; PF07714 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999927097) |
| Ortholog in Animals | Alpaca_ NPR2 ( ortholog_one2one ) Dog_ NPR2 ( ortholog_one2one ) GuineaPig_ NPR2 ( ortholog_one2one ) Macaque_ NPR2 ( ortholog_one2one ) Mouse_ Npr2 ( ortholog_one2one ) Pig_ NPR2 ( ortholog_one2one ) Rat_ Npr2 ( ortholog_one2one ) Rabbit_ NPR2 ( ortholog_one2one ) |
| Ohnologs | NPR1 |
| Paralogs | ADCY8, GUCY1B1, ADCY7, ADCY3, GUCY1A1, ADCY1, NPR1, ADCY9, ADCY6, GUCY2C, GUCY2D, GUCY1A2, ADCY4, ADCY5, ADCY2, GUCY2F, NPR3 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.08(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs28931581 rs796065355 rs758478717 rs28931582 rs28929479 rs768423636 rs55747238 rs139036657 rs1313765432 rs1828087195 rs796065356 rs587777597 rs587777596 rs1314542724 rs1305337032 rs5816 rs1303913631 rs766256429 rs55700371 rs370158184 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:24001744, ECO:0000269|PubMed:26980729}; Single-pass type I membrane protein {ECO:0000305|PubMed:26980729}. |
| Mouse PG classification | HPG |
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