| Gene Information | |
|---|---|
| Gene Name | NPPC |
| Organism | Homo sapiens (Human) |
| Gene Length | 126 |
| Protein Names | C-type natriuretic peptide [Cleaved into: CNP-22; CNP-29; CNP-53] |
| Target Name | c-type natriuretic peptide |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000163273 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | P23582 |
| Gene Card | NPPC |
| Uniprot ID | P23582 |
| Pfam | PF00212 |
| In ASD | no |
| Allosteric Prediction | no (-0.237377986) |
| Ortholog in Animals | Alpaca_ NPPC ( ortholog_one2one ) Dog_ NPPC ( ortholog_one2one ) GuineaPig_ NPPC ( ortholog_one2one ) Macaque_ NPPC ( ortholog_one2one ) Mouse_ Nppc ( ortholog_one2one ) Pig_ NPPC ( ortholog_one2one ) Rat_ Nppc ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | [CNP-22]: In the kidney, predominantly expressed in the distal tubular cells (at protein level). {ECO:0000269|PubMed:9794555}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);0.200000(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1JDP (X-ray 2.00A ) |
| DBSNP | rs5267 |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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