| Gene Information | |
|---|---|
| Gene Name | NPL |
| Organism | Homo sapiens (Human) |
| Gene Length | 320 |
| Protein Names | N-acetylneuraminate lyase (NALase) (EC 4.1.3.3) (N-acetylneuraminate pyruvate-lyase) (N-acetylneuraminic acid aldolase) (Sialate lyase) (Sialate-pyruvate lyase) (Sialic acid aldolase) (Sialic acid lyase) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000135838 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9BXD5 |
| Gene Card | NPL |
| Uniprot ID | Q9BXD5 |
| Pfam | PF00701 |
| In ASD | no |
| Allosteric Prediction | no (-0.356656063) |
| Ortholog in Animals | Alpaca_ NPL ( ortholog_one2one ) Dog_ NPL ( ortholog_one2one ) GuineaPig_ NPL ( ortholog_one2one ) Macaque_ NPL ( ortholog_one2one ) Mouse_ Npl ( ortholog_one2one ) Pig_ NPL ( ortholog_one2one ) Rat_ Npl ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | HOGA1 |
| Tissue | NA |
| Tissue Specificity | Isoform 2 is expressed in placenta, liver, kidney, pancreas, spleen, thymus, ovary, small intestine and peripheral blood leukocyte. {ECO:0000269|PubMed:16147865}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 6ARH (X-ray 1.60A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. |
| Mouse PG classification | NA |
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